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α-Glucosidase Inhibitory Flavonoids and Oxepinones from the Leaf and Twig Extracts of Desmos cochinchinensis

Journal Article


Abstract


  • Four new flavonoids (1-4), a new benzyl benzoate derivative (5), five new oxepinones (6-10), and 14 known compounds (11-24) were isolated from the leaf and twig extracts of Desmos cochinchinensis. Their structures were established by spectroscopic methods. The structure of 1 was also confirmed by X-ray diffraction data. The absolute configurations of 3, 4, and 6-10 were determined from comparisons of their ECD spectra with those of relevant reported compounds. Compounds 1, 2, 6, 8, 10, 12-15, and 17 showed α-glucosidase inhibitory activities with IC 50 values ranging from 0.2 to 4.9 μM.

Publication Date


  • 2019

Citation


  • Meesakul, P., Richardson, C., Pyne, S. G. & Laphookhieo, S. (2019). α-Glucosidase Inhibitory Flavonoids and Oxepinones from the Leaf and Twig Extracts of Desmos cochinchinensis. Journal of Natural Products, 82 (4), 741-747.

Scopus Eid


  • 2-s2.0-85062831857

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/648

Number Of Pages


  • 6

Start Page


  • 741

End Page


  • 747

Volume


  • 82

Issue


  • 4

Place Of Publication


  • United States

Abstract


  • Four new flavonoids (1-4), a new benzyl benzoate derivative (5), five new oxepinones (6-10), and 14 known compounds (11-24) were isolated from the leaf and twig extracts of Desmos cochinchinensis. Their structures were established by spectroscopic methods. The structure of 1 was also confirmed by X-ray diffraction data. The absolute configurations of 3, 4, and 6-10 were determined from comparisons of their ECD spectra with those of relevant reported compounds. Compounds 1, 2, 6, 8, 10, 12-15, and 17 showed α-glucosidase inhibitory activities with IC 50 values ranging from 0.2 to 4.9 μM.

Publication Date


  • 2019

Citation


  • Meesakul, P., Richardson, C., Pyne, S. G. & Laphookhieo, S. (2019). α-Glucosidase Inhibitory Flavonoids and Oxepinones from the Leaf and Twig Extracts of Desmos cochinchinensis. Journal of Natural Products, 82 (4), 741-747.

Scopus Eid


  • 2-s2.0-85062831857

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/648

Number Of Pages


  • 6

Start Page


  • 741

End Page


  • 747

Volume


  • 82

Issue


  • 4

Place Of Publication


  • United States