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A direct 3D suspension near-field electrospinning technique for the fabrication of polymer nanoarrays

Journal Article


Abstract


  • Near-field electrospinning (NFES) is widely recognized as a versatile nanofabrication method,

    one suitable for applications in tissue engineering. Rapid developments in this field have given

    rise to layered nanofibrous scaffolds. However, this electrostatic fabrication process is limited

    by the electric field inhibitory effects of polymer deposition. This leads to a major challenge:

    how to surpass this limitation on planar/layered constructs. While the current focus in this area

    largely lies with the investigation of new materials, techniques and increasing precision of

    NFES systems and patterning, exploration of complex collector substrates is often restricted by

    (i) available technology and (ii) access to complex electrode manufacturing tools. To achieve

    nanofiber arrays suspended in free space, this paper documents both the development of an

    integrated NFES system and the potential of standing electrodes manufactured via selective

    laser melting. This system was first tested by 2D patterning on planar silicon, using

    polyethylene oxide polymer solution. To demonstrate suspension NFES, two patterns

    operating within and around the standing electrodes produced high volume suspended

    nanoarrays. Image analysis of the arrays allowed for the assessment of fiber directionality and

    isotropy. By scanning electron microscopy, it was found that a mean fiber diameter of 310 nm

    of the arrays was achieved. Effectively manoeuvring between the electrode pillars required a

    precision automated system (unavailable off-the-shelf), developed in-house. This technique

    can be applied to the fabrication of nanofiber structures of sufficient volume for tissue

    engineering.

Publication Date


  • 2019

Citation


  • Nagle, A. R., Fay, C. D., Xie, Z., Wallace, G. G., Wang, X. & Higgins, M. J. (2019). A direct 3D suspension near-field electrospinning technique for the fabrication of polymer nanoarrays. Nanotechnology, 30 (19), 195301-1-195301-10.

Scopus Eid


  • 2-s2.0-85062436926

Start Page


  • 195301-1

End Page


  • 195301-10

Volume


  • 30

Issue


  • 19

Place Of Publication


  • United Kingdom

Abstract


  • Near-field electrospinning (NFES) is widely recognized as a versatile nanofabrication method,

    one suitable for applications in tissue engineering. Rapid developments in this field have given

    rise to layered nanofibrous scaffolds. However, this electrostatic fabrication process is limited

    by the electric field inhibitory effects of polymer deposition. This leads to a major challenge:

    how to surpass this limitation on planar/layered constructs. While the current focus in this area

    largely lies with the investigation of new materials, techniques and increasing precision of

    NFES systems and patterning, exploration of complex collector substrates is often restricted by

    (i) available technology and (ii) access to complex electrode manufacturing tools. To achieve

    nanofiber arrays suspended in free space, this paper documents both the development of an

    integrated NFES system and the potential of standing electrodes manufactured via selective

    laser melting. This system was first tested by 2D patterning on planar silicon, using

    polyethylene oxide polymer solution. To demonstrate suspension NFES, two patterns

    operating within and around the standing electrodes produced high volume suspended

    nanoarrays. Image analysis of the arrays allowed for the assessment of fiber directionality and

    isotropy. By scanning electron microscopy, it was found that a mean fiber diameter of 310 nm

    of the arrays was achieved. Effectively manoeuvring between the electrode pillars required a

    precision automated system (unavailable off-the-shelf), developed in-house. This technique

    can be applied to the fabrication of nanofiber structures of sufficient volume for tissue

    engineering.

Publication Date


  • 2019

Citation


  • Nagle, A. R., Fay, C. D., Xie, Z., Wallace, G. G., Wang, X. & Higgins, M. J. (2019). A direct 3D suspension near-field electrospinning technique for the fabrication of polymer nanoarrays. Nanotechnology, 30 (19), 195301-1-195301-10.

Scopus Eid


  • 2-s2.0-85062436926

Start Page


  • 195301-1

End Page


  • 195301-10

Volume


  • 30

Issue


  • 19

Place Of Publication


  • United Kingdom