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Dual Gold‐Catalyzed Cycloaromatization of Unconjugated (E)‐Enediynes

Journal Article


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Abstract


  • A synthesis of novel unconjugated (E)‐enediynes from allenyl amino alcohols is reported and their gold‐catalyzed cascade cycloaromatization to a broad range of enantioenriched substituted isoindolinones developed. Experimental and computational studies support the reaction proceeding via a dual‐gold σ,π‐activation mode involving a key gold‐vinylidene and allenyl‐gold containing intermediate.

UOW Authors


  •   Zamani, Farzad (external author)
  •   Babaahmadi, Rasool (external author)
  •   Yates, Brian F. (external author)
  •   Gardiner, Michael G. (external author)
  •   Ariafard, Alireza (external author)
  •   Pyne, Stephen
  •   Hyland, Christopher

Publication Date


  • 2019

Citation


  • Zamani, F., Babaahmadi, R., Yates, B. F., Gardiner, M. G., Ariafard, A., Pyne, S. G. & Hyland, C. J. T. (2019). Dual Gold‐Catalyzed Cycloaromatization of Unconjugated (E)‐Enediynes. Angewandte Chemie International Edition, 58 (7), 2114-2119.

Scopus Eid


  • 2-s2.0-85060191975

Ro Full-text Url


  • https://ro.uow.edu.au/context/smhpapers1/article/1531/type/native/viewcontent

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/519

Number Of Pages


  • 5

Start Page


  • 2114

End Page


  • 2119

Volume


  • 58

Issue


  • 7

Place Of Publication


  • Germany

Abstract


  • A synthesis of novel unconjugated (E)‐enediynes from allenyl amino alcohols is reported and their gold‐catalyzed cascade cycloaromatization to a broad range of enantioenriched substituted isoindolinones developed. Experimental and computational studies support the reaction proceeding via a dual‐gold σ,π‐activation mode involving a key gold‐vinylidene and allenyl‐gold containing intermediate.

UOW Authors


  •   Zamani, Farzad (external author)
  •   Babaahmadi, Rasool (external author)
  •   Yates, Brian F. (external author)
  •   Gardiner, Michael G. (external author)
  •   Ariafard, Alireza (external author)
  •   Pyne, Stephen
  •   Hyland, Christopher

Publication Date


  • 2019

Citation


  • Zamani, F., Babaahmadi, R., Yates, B. F., Gardiner, M. G., Ariafard, A., Pyne, S. G. & Hyland, C. J. T. (2019). Dual Gold‐Catalyzed Cycloaromatization of Unconjugated (E)‐Enediynes. Angewandte Chemie International Edition, 58 (7), 2114-2119.

Scopus Eid


  • 2-s2.0-85060191975

Ro Full-text Url


  • https://ro.uow.edu.au/context/smhpapers1/article/1531/type/native/viewcontent

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/519

Number Of Pages


  • 5

Start Page


  • 2114

End Page


  • 2119

Volume


  • 58

Issue


  • 7

Place Of Publication


  • Germany