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Antibacterial and cytotoxic activities of phenolic constituents from the stem extracts of Spatholobus parviflorus

Journal Article


Abstract


  • A new 2-arylbenzofuran, spathobenzofuran (1), together with ten known compounds including a 2-arylbenzofuran, three pterocarpans and six isoflavones were isolated from the acetone crude extract of the stems of Spatholobus parviflorus. All compounds were characterised by spectroscopic methods. Compound 4 was active (MIC 8 µg/mL) against Gram-negative Pseudomonas aeruginosa TISTR 781 while compound 2 had modest activity against Gram-positive Staphylococcus aureus TISTR 1466 with a MIC value of 16 µg/mL. All isolated compounds showed no cytotoxicity against Vero and KB cells.

UOW Authors


  •   Promchai, Thanika (external author)
  •   Janhom, Pawinee (external author)
  •   Maneerat, Wisanu (external author)
  •   Rattanajak, Roonglawan (external author)
  •   Kamchonwongpaisan, Sumalee (external author)
  •   Pyne, Stephen
  •   Limtharakul, Thunwadee (external author)

Publication Date


  • 2018

Citation


  • Promchai, T., Janhom, P., Maneerat, W., Rattanajak, R., Kamchonwongpaisan, S., Pyne, S. G. & Limtharakul, T. (2018). Antibacterial and cytotoxic activities of phenolic constituents from the stem extracts of Spatholobus parviflorus. Natural Product Research, Online First 1-5.

Scopus Eid


  • 2-s2.0-85059066859

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/491

Number Of Pages


  • 4

Start Page


  • 1

End Page


  • 5

Volume


  • Online First

Place Of Publication


  • United Kingdom

Abstract


  • A new 2-arylbenzofuran, spathobenzofuran (1), together with ten known compounds including a 2-arylbenzofuran, three pterocarpans and six isoflavones were isolated from the acetone crude extract of the stems of Spatholobus parviflorus. All compounds were characterised by spectroscopic methods. Compound 4 was active (MIC 8 µg/mL) against Gram-negative Pseudomonas aeruginosa TISTR 781 while compound 2 had modest activity against Gram-positive Staphylococcus aureus TISTR 1466 with a MIC value of 16 µg/mL. All isolated compounds showed no cytotoxicity against Vero and KB cells.

UOW Authors


  •   Promchai, Thanika (external author)
  •   Janhom, Pawinee (external author)
  •   Maneerat, Wisanu (external author)
  •   Rattanajak, Roonglawan (external author)
  •   Kamchonwongpaisan, Sumalee (external author)
  •   Pyne, Stephen
  •   Limtharakul, Thunwadee (external author)

Publication Date


  • 2018

Citation


  • Promchai, T., Janhom, P., Maneerat, W., Rattanajak, R., Kamchonwongpaisan, S., Pyne, S. G. & Limtharakul, T. (2018). Antibacterial and cytotoxic activities of phenolic constituents from the stem extracts of Spatholobus parviflorus. Natural Product Research, Online First 1-5.

Scopus Eid


  • 2-s2.0-85059066859

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/491

Number Of Pages


  • 4

Start Page


  • 1

End Page


  • 5

Volume


  • Online First

Place Of Publication


  • United Kingdom