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Potent α-glucosidase inhibitory activity of compounds isolated from the leaf extracts of Uvaria hamiltonii

Journal Article


Abstract


  • The phytochemical investigation of the leaf extracts of Uvaria hamiltonii (Annonaceae) led to the isolation and identification of ten compounds including a new seco-cyclohexene (1) together with nine known compounds (2–10). Their structures were elucidated by intensive analysis by spectroscopic methods and comparisons of their spectroscopic data with those of compounds reported in the literature. Compounds 2, 8, and 9 showed potent α-glucosidase inhibitory activity with the IC50 values ranging from 2.6–7.1 µM.

UOW Authors


  •   Meesakul, Pornphimol (external author)
  •   Pyne, Stephen
  •   Laphookhieo, Surat (external author)

Publication Date


  • 2018

Citation


  • Meesakul, P., Pyne, S. G. & Laphookhieo, S. (2018). Potent α-glucosidase inhibitory activity of compounds isolated from the leaf extracts of Uvaria hamiltonii. Natural Product Research, Online First 1-5.

Scopus Eid


  • 2-s2.0-85059092793

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/490

Number Of Pages


  • 4

Start Page


  • 1

End Page


  • 5

Volume


  • Online First

Place Of Publication


  • Switzerland

Abstract


  • The phytochemical investigation of the leaf extracts of Uvaria hamiltonii (Annonaceae) led to the isolation and identification of ten compounds including a new seco-cyclohexene (1) together with nine known compounds (2–10). Their structures were elucidated by intensive analysis by spectroscopic methods and comparisons of their spectroscopic data with those of compounds reported in the literature. Compounds 2, 8, and 9 showed potent α-glucosidase inhibitory activity with the IC50 values ranging from 2.6–7.1 µM.

UOW Authors


  •   Meesakul, Pornphimol (external author)
  •   Pyne, Stephen
  •   Laphookhieo, Surat (external author)

Publication Date


  • 2018

Citation


  • Meesakul, P., Pyne, S. G. & Laphookhieo, S. (2018). Potent α-glucosidase inhibitory activity of compounds isolated from the leaf extracts of Uvaria hamiltonii. Natural Product Research, Online First 1-5.

Scopus Eid


  • 2-s2.0-85059092793

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/490

Number Of Pages


  • 4

Start Page


  • 1

End Page


  • 5

Volume


  • Online First

Place Of Publication


  • Switzerland