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Substitution of fish for red meat or poultry and risk of ischemic stroke

Journal Article


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Abstract


  • We investigated the risk of ischemic stroke and its subtypes when red meat or poultry was substituted with fish. A total of 57,053 participants aged 50–65 years at baseline were included in the Danish Diet, Cancer and Health study. All participants filled in a food-frequency questionnaire at recruitment. Potential ischemic stroke cases were identified by linkage to the Danish National Patient Register, and all cases were validated and subclassified. Substitutions were investigated as 150 g/week of fish for 150 g/week of red meat or of poultry using multivariable Cox proportional hazard regression models. During 13.5 years of follow-up, 1879 participants developed an ischemic stroke. Replacing red meat or poultry with fish was not associated with the rate of total ischemic stroke, but there was a statistically significant lower rate of large artery atherosclerosis when fish replaced processed (hazard ratio (HR): 0.78; 95% confidence interval (CI): 0.67; 0.90) and unprocessed (HR: 0.87; 95% CI: 0.75; 0.99) red meat. A statistically significant higher rate of cardioembolism was found when poultry was replaced by total fish (HR: 1.42; 95% CI: 1.04; 1.93). When fatty fish replaced unprocessed red meat, a statistically significant lower rate of small-vessel occlusion was found (HR: 0.88; 95% CI: 0.77; 0.99). In conclusion, replacing red meat with fish was not associated with risk of total ischemic stroke but was associated with a lower risk of subtypes of ischemic stroke.

UOW Authors


  •   Veno, Stine K. (external author)
  •   Bork, Christian S. (external author)
  •   Jakobsen, Marianne U. (external author)
  •   Lundbye-Christensen, Soren (external author)
  •   Bach, Flemming W. (external author)
  •   McLennan, Peter (external author)
  •   Tjonneland, Anne (external author)
  •   Schmidt, Erik B. (external author)
  •   Overvad, Kim (external author)

Publication Date


  • 2018

Citation


  • Veno, S. K., Bork, C. S., Jakobsen, M. U., Lundbye-Christensen, S., Bach, F. W., McLennan, P. L., Tjonneland, A., Schmidt, E. B. & Overvad, K. (2018). Substitution of fish for red meat or poultry and risk of ischemic stroke. Nutrients, 10 (11), 1648-1-1648-11.

Scopus Eid


  • 2-s2.0-85056113393

Ro Full-text Url


  • https://ro.uow.edu.au/cgi/viewcontent.cgi?article=1430&context=smhpapers1

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/418

Start Page


  • 1648-1

End Page


  • 1648-11

Volume


  • 10

Issue


  • 11

Place Of Publication


  • Switzerland

Abstract


  • We investigated the risk of ischemic stroke and its subtypes when red meat or poultry was substituted with fish. A total of 57,053 participants aged 50–65 years at baseline were included in the Danish Diet, Cancer and Health study. All participants filled in a food-frequency questionnaire at recruitment. Potential ischemic stroke cases were identified by linkage to the Danish National Patient Register, and all cases were validated and subclassified. Substitutions were investigated as 150 g/week of fish for 150 g/week of red meat or of poultry using multivariable Cox proportional hazard regression models. During 13.5 years of follow-up, 1879 participants developed an ischemic stroke. Replacing red meat or poultry with fish was not associated with the rate of total ischemic stroke, but there was a statistically significant lower rate of large artery atherosclerosis when fish replaced processed (hazard ratio (HR): 0.78; 95% confidence interval (CI): 0.67; 0.90) and unprocessed (HR: 0.87; 95% CI: 0.75; 0.99) red meat. A statistically significant higher rate of cardioembolism was found when poultry was replaced by total fish (HR: 1.42; 95% CI: 1.04; 1.93). When fatty fish replaced unprocessed red meat, a statistically significant lower rate of small-vessel occlusion was found (HR: 0.88; 95% CI: 0.77; 0.99). In conclusion, replacing red meat with fish was not associated with risk of total ischemic stroke but was associated with a lower risk of subtypes of ischemic stroke.

UOW Authors


  •   Veno, Stine K. (external author)
  •   Bork, Christian S. (external author)
  •   Jakobsen, Marianne U. (external author)
  •   Lundbye-Christensen, Soren (external author)
  •   Bach, Flemming W. (external author)
  •   McLennan, Peter (external author)
  •   Tjonneland, Anne (external author)
  •   Schmidt, Erik B. (external author)
  •   Overvad, Kim (external author)

Publication Date


  • 2018

Citation


  • Veno, S. K., Bork, C. S., Jakobsen, M. U., Lundbye-Christensen, S., Bach, F. W., McLennan, P. L., Tjonneland, A., Schmidt, E. B. & Overvad, K. (2018). Substitution of fish for red meat or poultry and risk of ischemic stroke. Nutrients, 10 (11), 1648-1-1648-11.

Scopus Eid


  • 2-s2.0-85056113393

Ro Full-text Url


  • https://ro.uow.edu.au/cgi/viewcontent.cgi?article=1430&context=smhpapers1

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/418

Start Page


  • 1648-1

End Page


  • 1648-11

Volume


  • 10

Issue


  • 11

Place Of Publication


  • Switzerland