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3D printing of nanocellulose hydrogel scaffolds with tunable mechanical strength towards wound healing application

Journal Article


Abstract


  • We present for the first time approaches to 3D-printing of nanocellulose hydrogel scaffolds based on double crosslinking, first by in situ Ca2+ crosslinking and post-printing by chemical crosslinking with 1,4-butanediol diglycidyl ether (BDDE). Scaffolds were successfully printed from 1% nanocellulose hydrogels, with their mechanical strength being tunable in the range of 3 to 8 kPa. Cell tests suggest that the 3D-printed and BDDE-crosslinked nanocellulose hydrogel scaffolds supported fibroblast cells' proliferation, which was improving with increasing rigidity. These 3D-printed scaffolds render nanocellulose a new member of the family of promising support structures for crucial cellular processes during wound healing, regeneration and tissue repair.

Authors


  •   Xu, Chunlin (external author)
  •   Zhang, Binbin (external author)
  •   Wang, Xiaoju (external author)
  •   Cheng, Fang (external author)
  •   Xu, Wenyang (external author)
  •   Molino, Paul J.
  •   Bacher, Markus (external author)
  •   Su, Dandan (external author)
  •   Rosenau, Thomas (external author)
  •   Willfor, Stefan (external author)
  •   Wallace, Gordon G.

Publication Date


  • 2018

Citation


  • Xu, C., Zhang Molino, B., Wang, X., Cheng, F., Xu, W., Molino, P., Bacher, M., Su, D., Rosenau, T., Willfor, S. & Wallace, G. (2018). 3D printing of nanocellulose hydrogel scaffolds with tunable mechanical strength towards wound healing application. Journal of Materials Chemistry B, 6 (43), 7066-7075.

Scopus Eid


  • 2-s2.0-85056336497

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/3355

Number Of Pages


  • 9

Start Page


  • 7066

End Page


  • 7075

Volume


  • 6

Issue


  • 43

Place Of Publication


  • United Kingdom

Abstract


  • We present for the first time approaches to 3D-printing of nanocellulose hydrogel scaffolds based on double crosslinking, first by in situ Ca2+ crosslinking and post-printing by chemical crosslinking with 1,4-butanediol diglycidyl ether (BDDE). Scaffolds were successfully printed from 1% nanocellulose hydrogels, with their mechanical strength being tunable in the range of 3 to 8 kPa. Cell tests suggest that the 3D-printed and BDDE-crosslinked nanocellulose hydrogel scaffolds supported fibroblast cells' proliferation, which was improving with increasing rigidity. These 3D-printed scaffolds render nanocellulose a new member of the family of promising support structures for crucial cellular processes during wound healing, regeneration and tissue repair.

Authors


  •   Xu, Chunlin (external author)
  •   Zhang, Binbin (external author)
  •   Wang, Xiaoju (external author)
  •   Cheng, Fang (external author)
  •   Xu, Wenyang (external author)
  •   Molino, Paul J.
  •   Bacher, Markus (external author)
  •   Su, Dandan (external author)
  •   Rosenau, Thomas (external author)
  •   Willfor, Stefan (external author)
  •   Wallace, Gordon G.

Publication Date


  • 2018

Citation


  • Xu, C., Zhang Molino, B., Wang, X., Cheng, F., Xu, W., Molino, P., Bacher, M., Su, D., Rosenau, T., Willfor, S. & Wallace, G. (2018). 3D printing of nanocellulose hydrogel scaffolds with tunable mechanical strength towards wound healing application. Journal of Materials Chemistry B, 6 (43), 7066-7075.

Scopus Eid


  • 2-s2.0-85056336497

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/3355

Number Of Pages


  • 9

Start Page


  • 7066

End Page


  • 7075

Volume


  • 6

Issue


  • 43

Place Of Publication


  • United Kingdom