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Microdosimetric applications in proton and heavy ion therapy using silicon microdosimeters

Journal Article


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Abstract


  • Using the CMRP ‘bridge' μ+ probe, microdosimetric measurements were undertaken out-of-field using a therapeutic scanning proton pencil beam and in-field using a 12C ion therapy field. These measurements were undertaken at Mayo Clinic, Rochester, USA and at HIMAC, Chiba, Japan, respectively. For a typical proton field used in the treatment of deep-seated tumors, we observed dose-equivalent values ranging from 0.62 to 0.99 mSv/Gy at locations downstream of the distal edge. Lateral measurements at depths close to the entrance and along the SOBP plateau were found to reach maximum values of 3.1 mSv/Gy and 5.3 mSv/Gy at 10 mm from the field edge, respectively, and decreased to ~0.04 mSv/Gy 120 mm from the field edge. The ability to measure the dose-equivalent with high spatial resolution is particularly relevant to healthy tissue dose calculations in hadron therapy treatments. We have also shown qualitatively and quantitively the effects critical organ motion would have in treatment using microdosimetric spectra. Large differences in spectra and RBE10 were observed for treatments where miscalculations of 12C ion range would result in critical structures being irradiated, showing the importance of motion management.

Publication Date


  • 2018

Citation


  • Chartier, L., Tran, L. T., Bolst, D., Guatelli, S., Pogossov, A., Prokopovich, D. A., Reinhard, M. I., Perevertaylo, V., Anderson, S., Beltran, C., Matsufuji, N., Jackson, M. & Rosenfeld, A. B. (2018). Microdosimetric applications in proton and heavy ion therapy using silicon microdosimeters. Radiation Protection Dosimetry, 180 (1-4), 365-371.

Scopus Eid


  • 2-s2.0-85055106049

Ro Full-text Url


  • https://ro.uow.edu.au/cgi/viewcontent.cgi?article=3178&context=eispapers1

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers1/2172

Number Of Pages


  • 6

Start Page


  • 365

End Page


  • 371

Volume


  • 180

Issue


  • 1-4

Place Of Publication


  • United Kingdom

Abstract


  • Using the CMRP ‘bridge' μ+ probe, microdosimetric measurements were undertaken out-of-field using a therapeutic scanning proton pencil beam and in-field using a 12C ion therapy field. These measurements were undertaken at Mayo Clinic, Rochester, USA and at HIMAC, Chiba, Japan, respectively. For a typical proton field used in the treatment of deep-seated tumors, we observed dose-equivalent values ranging from 0.62 to 0.99 mSv/Gy at locations downstream of the distal edge. Lateral measurements at depths close to the entrance and along the SOBP plateau were found to reach maximum values of 3.1 mSv/Gy and 5.3 mSv/Gy at 10 mm from the field edge, respectively, and decreased to ~0.04 mSv/Gy 120 mm from the field edge. The ability to measure the dose-equivalent with high spatial resolution is particularly relevant to healthy tissue dose calculations in hadron therapy treatments. We have also shown qualitatively and quantitively the effects critical organ motion would have in treatment using microdosimetric spectra. Large differences in spectra and RBE10 were observed for treatments where miscalculations of 12C ion range would result in critical structures being irradiated, showing the importance of motion management.

Publication Date


  • 2018

Citation


  • Chartier, L., Tran, L. T., Bolst, D., Guatelli, S., Pogossov, A., Prokopovich, D. A., Reinhard, M. I., Perevertaylo, V., Anderson, S., Beltran, C., Matsufuji, N., Jackson, M. & Rosenfeld, A. B. (2018). Microdosimetric applications in proton and heavy ion therapy using silicon microdosimeters. Radiation Protection Dosimetry, 180 (1-4), 365-371.

Scopus Eid


  • 2-s2.0-85055106049

Ro Full-text Url


  • https://ro.uow.edu.au/cgi/viewcontent.cgi?article=3178&context=eispapers1

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers1/2172

Number Of Pages


  • 6

Start Page


  • 365

End Page


  • 371

Volume


  • 180

Issue


  • 1-4

Place Of Publication


  • United Kingdom