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Commentary: GLYX-13 Ameliorates Schizophrenia-Like Phenotype Induced by MK-801 in Mice: Role of Hippocampal NR2B and DISC1

Journal Article


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Abstract


  • It is with great interest we have read the article “GLYX-13 Ameliorates Schizophrenia-Like Phenotype Induced by MK-801 in Mice: Role of Hippocampal NR2B and DISC1” (Zhou et al., 2018).

    Interestingly, this study showed that GLYX-13 prevents hippocampal N-methyl-D-aspartate receptor subtype 2B—Disrupted in schizophrenia 1 (GluN2B-DISC1) signaling and behavioural changes induced by schizophrenia-mimetic drug MK801 in mice. To confirm GluN2B directly regulating DISC1, these researchers showed that the effects of GLYX-13 were vanished after GluN2B knockdown in mice.

Publication Date


  • 2018

Citation


  • Xie, Y. & Huang, X. (2018). Commentary: GLYX-13 Ameliorates Schizophrenia-Like Phenotype Induced by MK-801 in Mice: Role of Hippocampal NR2B and DISC1. Frontiers in Molecular Neuroscience, 11 315-1-315-3.

Scopus Eid


  • 2-s2.0-85054869166

Ro Full-text Url


  • https://ro.uow.edu.au/cgi/viewcontent.cgi?article=2353&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/1326

Start Page


  • 315-1

End Page


  • 315-3

Volume


  • 11

Place Of Publication


  • Switzerland

Abstract


  • It is with great interest we have read the article “GLYX-13 Ameliorates Schizophrenia-Like Phenotype Induced by MK-801 in Mice: Role of Hippocampal NR2B and DISC1” (Zhou et al., 2018).

    Interestingly, this study showed that GLYX-13 prevents hippocampal N-methyl-D-aspartate receptor subtype 2B—Disrupted in schizophrenia 1 (GluN2B-DISC1) signaling and behavioural changes induced by schizophrenia-mimetic drug MK801 in mice. To confirm GluN2B directly regulating DISC1, these researchers showed that the effects of GLYX-13 were vanished after GluN2B knockdown in mice.

Publication Date


  • 2018

Citation


  • Xie, Y. & Huang, X. (2018). Commentary: GLYX-13 Ameliorates Schizophrenia-Like Phenotype Induced by MK-801 in Mice: Role of Hippocampal NR2B and DISC1. Frontiers in Molecular Neuroscience, 11 315-1-315-3.

Scopus Eid


  • 2-s2.0-85054869166

Ro Full-text Url


  • https://ro.uow.edu.au/cgi/viewcontent.cgi?article=2353&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/1326

Start Page


  • 315-1

End Page


  • 315-3

Volume


  • 11

Place Of Publication


  • Switzerland