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Alkaloids and styryllactones from Goniothalamus cheliensis

Journal Article


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Abstract


  • Eight previously undescribed compounds, including four alkaloids and five styryllactones together with 36 known compounds were isolated from the twig and leaf extracts of Goniothalamus cheliensis. Their structures were elucidated by extensive analysis of their spectroscopic data. The absolute configuration of (−)-(4S,5S,6R,7S,8S)-goniochelienlactone and (−)-(4S,5S,6R,7S,8S)-7-acetylgoniochelienlactone were established from single crystal X-ray analysis using Cu Kα radiation. The absolute configurations of the other related compounds were identified by comparisons of their ECD spectra with those of related known compounds. Most of the isolated compounds were evaluated for their cytotoxicities against human colorectal cancer cells (HCT-116). Griffithazanone A was the most potent with an IC50 value of 2.39 μM.

UOW Authors


  •   Jaidee, Wuttichai (external author)
  •   Andersen, Raymond J. (external author)
  •   Patrick, Brian O. (external author)
  •   Pyne, Stephen
  •   Muanprasat, Chatchai (external author)
  •   Borwornpinyo, Suparerk (external author)
  •   Laphookhieo, Surat (external author)

Publication Date


  • 2019

Citation


  • Jaidee, W., Andersen, R. J., Patrick, B. O., Pyne, S. G., Muanprasat, C., Borwornpinyo, S. & Laphookhieo, S. (2019). Alkaloids and styryllactones from Goniothalamus cheliensis. Phytochemistry, 157 8-20.

Scopus Eid


  • 2-s2.0-85055991898

Ro Full-text Url


  • https://ro.uow.edu.au/cgi/viewcontent.cgi?article=1278&context=smhpapers1

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/274

Number Of Pages


  • 12

Start Page


  • 8

End Page


  • 20

Volume


  • 157

Place Of Publication


  • United Kingdom

Abstract


  • Eight previously undescribed compounds, including four alkaloids and five styryllactones together with 36 known compounds were isolated from the twig and leaf extracts of Goniothalamus cheliensis. Their structures were elucidated by extensive analysis of their spectroscopic data. The absolute configuration of (−)-(4S,5S,6R,7S,8S)-goniochelienlactone and (−)-(4S,5S,6R,7S,8S)-7-acetylgoniochelienlactone were established from single crystal X-ray analysis using Cu Kα radiation. The absolute configurations of the other related compounds were identified by comparisons of their ECD spectra with those of related known compounds. Most of the isolated compounds were evaluated for their cytotoxicities against human colorectal cancer cells (HCT-116). Griffithazanone A was the most potent with an IC50 value of 2.39 μM.

UOW Authors


  •   Jaidee, Wuttichai (external author)
  •   Andersen, Raymond J. (external author)
  •   Patrick, Brian O. (external author)
  •   Pyne, Stephen
  •   Muanprasat, Chatchai (external author)
  •   Borwornpinyo, Suparerk (external author)
  •   Laphookhieo, Surat (external author)

Publication Date


  • 2019

Citation


  • Jaidee, W., Andersen, R. J., Patrick, B. O., Pyne, S. G., Muanprasat, C., Borwornpinyo, S. & Laphookhieo, S. (2019). Alkaloids and styryllactones from Goniothalamus cheliensis. Phytochemistry, 157 8-20.

Scopus Eid


  • 2-s2.0-85055991898

Ro Full-text Url


  • https://ro.uow.edu.au/cgi/viewcontent.cgi?article=1278&context=smhpapers1

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/274

Number Of Pages


  • 12

Start Page


  • 8

End Page


  • 20

Volume


  • 157

Place Of Publication


  • United Kingdom