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Four new C-benzyl flavonoids from the fruit of Uvaria cherrevensis

Journal Article


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Abstract


  • The phytochemical investigation of the fruit extracts of Uvaria cherrevensis led to the isolation and characterization of four new C-benzyl flavonoids; cherrevenones A-D (1–4) together with 11 known compounds. The isolated compounds were characterized using spectroscopic techniques. Compounds 1, 3, 5 and 11 showed moderate inhibitory activities against the P. falciparum strains TM4/8.2 and K1CB1 with IC50 values ranging from 21.0 ± 3.10 – 33.7 ± 7.69 and 21.0 ± 5.44 – 43.5 ± 11.9 μM, respectively. Compounds 1, 2, 5, 10 and 11 exhibited strong cytotoxic activities against KB cells with IC50 values ranging from 0.60 ± 0.17 – 4.91 ± 2.69 μM which were similar to their cytotoxic activities found against Vero cells, except for compound 5, which was non-toxic to Vero cells.

UOW Authors


  •   Auranwiwat, Chiramet (external author)
  •   Rattanajak, Roonglawan (external author)
  •   Kamchonwongpaisan, Sumalee (external author)
  •   Laphookhieo, Surat (external author)
  •   Pyne, Stephen
  •   Limtharakul, Thunwadee (external author)

Publication Date


  • 2018

Citation


  • Auranwiwat, C., Rattanajak, R., Kamchonwongpaisan, S., Laphookhieo, S., Pyne, S. G. & Limtharakul, T. (2018). Four new C-benzyl flavonoids from the fruit of Uvaria cherrevensis. Fitoterapia, 130 198-202.

Scopus Eid


  • 2-s2.0-85053160199

Ro Full-text Url


  • https://ro.uow.edu.au/cgi/viewcontent.cgi?article=1198&context=smhpapers1

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/195

Number Of Pages


  • 4

Start Page


  • 198

End Page


  • 202

Volume


  • 130

Place Of Publication


  • Italy

Abstract


  • The phytochemical investigation of the fruit extracts of Uvaria cherrevensis led to the isolation and characterization of four new C-benzyl flavonoids; cherrevenones A-D (1–4) together with 11 known compounds. The isolated compounds were characterized using spectroscopic techniques. Compounds 1, 3, 5 and 11 showed moderate inhibitory activities against the P. falciparum strains TM4/8.2 and K1CB1 with IC50 values ranging from 21.0 ± 3.10 – 33.7 ± 7.69 and 21.0 ± 5.44 – 43.5 ± 11.9 μM, respectively. Compounds 1, 2, 5, 10 and 11 exhibited strong cytotoxic activities against KB cells with IC50 values ranging from 0.60 ± 0.17 – 4.91 ± 2.69 μM which were similar to their cytotoxic activities found against Vero cells, except for compound 5, which was non-toxic to Vero cells.

UOW Authors


  •   Auranwiwat, Chiramet (external author)
  •   Rattanajak, Roonglawan (external author)
  •   Kamchonwongpaisan, Sumalee (external author)
  •   Laphookhieo, Surat (external author)
  •   Pyne, Stephen
  •   Limtharakul, Thunwadee (external author)

Publication Date


  • 2018

Citation


  • Auranwiwat, C., Rattanajak, R., Kamchonwongpaisan, S., Laphookhieo, S., Pyne, S. G. & Limtharakul, T. (2018). Four new C-benzyl flavonoids from the fruit of Uvaria cherrevensis. Fitoterapia, 130 198-202.

Scopus Eid


  • 2-s2.0-85053160199

Ro Full-text Url


  • https://ro.uow.edu.au/cgi/viewcontent.cgi?article=1198&context=smhpapers1

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/195

Number Of Pages


  • 4

Start Page


  • 198

End Page


  • 202

Volume


  • 130

Place Of Publication


  • Italy