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Antioxidant neolignans from the twigs and leaves of Mitrephora wangii HU

Journal Article


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Abstract


  • Two new compounds, odoratisol E (1) and decurrenal A (2), together with 12 known compounds were isolated from the twig and leaf extracts of Mitrephora wangii HU (Annonaceae). All structures were elucidated by spectroscopic methods. The structure of compound (+)-6 was also confirmed by X-ray diffraction analysis. The absolute configurations of odoratisol E and decurrenal A were determined by comparison of their electronic circular dichroism (ECD) spectra with those of related known compounds. Most of the isolated compounds were evaluated for their antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays. Compounds 4 and (+)-6 displayed potent ABTS radical scavenging activity with IC50 values of 11.9 ± 1.8 and 10.8 ± 1.7 μM, respectively, which is better than that of standard compound, ascorbic acid, (IC50 = 19.3 ± 0.1 μM). Compound 9 showed moderate DPPH radical scavenging activity with an IC50 value of 38.7 ± 0.8 μM.

UOW Authors


  •   Jaidee, Wuttichai (external author)
  •   Maneerat, Wisanu (external author)
  •   Andersen, Raymond J. (external author)
  •   Patrick, Brian O. (external author)
  •   Pyne, Stephen
  •   Laphookhieo, Surat (external author)

Publication Date


  • 2018

Citation


  • Jaidee, W., Maneerat, W., Andersen, R. J., Patrick, B. O., Pyne, S. G. & Laphookhieo, S. (2018). Antioxidant neolignans from the twigs and leaves of Mitrephora wangii HU. Fitoterapia, 130 219-224.

Scopus Eid


  • 2-s2.0-85053395099

Ro Full-text Url


  • https://ro.uow.edu.au/cgi/viewcontent.cgi?article=1197&context=smhpapers1

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/194

Number Of Pages


  • 5

Start Page


  • 219

End Page


  • 224

Volume


  • 130

Place Of Publication


  • Italy

Abstract


  • Two new compounds, odoratisol E (1) and decurrenal A (2), together with 12 known compounds were isolated from the twig and leaf extracts of Mitrephora wangii HU (Annonaceae). All structures were elucidated by spectroscopic methods. The structure of compound (+)-6 was also confirmed by X-ray diffraction analysis. The absolute configurations of odoratisol E and decurrenal A were determined by comparison of their electronic circular dichroism (ECD) spectra with those of related known compounds. Most of the isolated compounds were evaluated for their antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays. Compounds 4 and (+)-6 displayed potent ABTS radical scavenging activity with IC50 values of 11.9 ± 1.8 and 10.8 ± 1.7 μM, respectively, which is better than that of standard compound, ascorbic acid, (IC50 = 19.3 ± 0.1 μM). Compound 9 showed moderate DPPH radical scavenging activity with an IC50 value of 38.7 ± 0.8 μM.

UOW Authors


  •   Jaidee, Wuttichai (external author)
  •   Maneerat, Wisanu (external author)
  •   Andersen, Raymond J. (external author)
  •   Patrick, Brian O. (external author)
  •   Pyne, Stephen
  •   Laphookhieo, Surat (external author)

Publication Date


  • 2018

Citation


  • Jaidee, W., Maneerat, W., Andersen, R. J., Patrick, B. O., Pyne, S. G. & Laphookhieo, S. (2018). Antioxidant neolignans from the twigs and leaves of Mitrephora wangii HU. Fitoterapia, 130 219-224.

Scopus Eid


  • 2-s2.0-85053395099

Ro Full-text Url


  • https://ro.uow.edu.au/cgi/viewcontent.cgi?article=1197&context=smhpapers1

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/194

Number Of Pages


  • 5

Start Page


  • 219

End Page


  • 224

Volume


  • 130

Place Of Publication


  • Italy