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Antibacterial Prenylated Isoflavonoids from the Stems of Millettia extensa

Journal Article


Abstract


  • The first phytochemical investigation of the stem extract of Millettia extensa resulted in the isolation and identification of six new isoflavones, millexatins A-F (1-6), together with 16 known compounds. The structures of these new compounds were determined on the basis of their spectroscopic data. Millexatin A (1) is a rare isoflavone containing three isoprenyl units on a modified A ring. Compounds 1, 6, 10, 11, and 14 displayed promising antibacterial activity with MIC values of 2-8 μg/mL.

UOW Authors


  •   Raksat, Achara (external author)
  •   Maneerat, Wisanu (external author)
  •   Andersen, Raymond J. (external author)
  •   Pyne, Stephen
  •   Laphookhieo, Surat (external author)

Publication Date


  • 2018

Citation


  • Raksat, A., Maneerat, W., Andersen, R. J., Pyne, S. G. & Laphookhieo, S. (2018). Antibacterial Prenylated Isoflavonoids from the Stems of Millettia extensa. Journal of Natural Products, 81 (8), 1835-1840.

Scopus Eid


  • 2-s2.0-85052574085

Number Of Pages


  • 5

Start Page


  • 1835

End Page


  • 1840

Volume


  • 81

Issue


  • 8

Place Of Publication


  • United States

Abstract


  • The first phytochemical investigation of the stem extract of Millettia extensa resulted in the isolation and identification of six new isoflavones, millexatins A-F (1-6), together with 16 known compounds. The structures of these new compounds were determined on the basis of their spectroscopic data. Millexatin A (1) is a rare isoflavone containing three isoprenyl units on a modified A ring. Compounds 1, 6, 10, 11, and 14 displayed promising antibacterial activity with MIC values of 2-8 μg/mL.

UOW Authors


  •   Raksat, Achara (external author)
  •   Maneerat, Wisanu (external author)
  •   Andersen, Raymond J. (external author)
  •   Pyne, Stephen
  •   Laphookhieo, Surat (external author)

Publication Date


  • 2018

Citation


  • Raksat, A., Maneerat, W., Andersen, R. J., Pyne, S. G. & Laphookhieo, S. (2018). Antibacterial Prenylated Isoflavonoids from the Stems of Millettia extensa. Journal of Natural Products, 81 (8), 1835-1840.

Scopus Eid


  • 2-s2.0-85052574085

Number Of Pages


  • 5

Start Page


  • 1835

End Page


  • 1840

Volume


  • 81

Issue


  • 8

Place Of Publication


  • United States