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Harnessing the Postmortem Human Brain to Study Severe Psychiatric Disorders: Methodological Innovations and Paradigm Shifts

Conference Paper


Abstract


  • The postmortem human brain is a valuable resource for

    examining the biological basis of severe psychiatric disorders

    such as schizophrenia and bipolar disorder. Postmortem

    studies provide a snapshot of the biochemical and molecular

    processes occurring in the brain under pathological

    conditions, which can be problematic to otherwise model due

    to their polygenic aetiologies. In the last decade, the

    neuroscience field has largely shifted towards mainstream

    use of several new experimental techniques with

    unprecedented accuracy, the ability to extricate minute

    details and generate large amounts of data from small

    amounts of sample. Applications of these techniques are

    revolutionizing the field of postmortem brain research by

    dramatically improving the way postmortem tissues are being

    studied and integrated with other evidence from

    neuroscience. The aim of this symposium is to convincingly

    convey this paradigm shift in human postmortem brain

    research. The works described by all our speakers showcase

    new techniques at the forefront of psychiatric neuroscience

    that have advanced the way we use postmortem tissues to

    identify molecular and neuroanatomical alterations that

    contribute to the manifestation of severe psychiatric

    conditions. As postmortem studies are especially valuable for

    directing and prioritizing future in vitro or in vivo

    experimental work, this symposium will be relevant to a wide audience outside of the postmortem research field. Focusing

    on new technologies, better scientific processes and paradigm

    shifts in psychiatry will not only consolidate and realign the

    postmortem research field, but provide a highly informed

    symposium which will ultimately improve our understanding

    of severe psychiatric conditions.

Publication Date


  • 2016

Citation


  • Matosin, N. & Meador-Woodruff, J. H. (2016). Harnessing the Postmortem Human Brain to Study Severe Psychiatric Disorders: Methodological Innovations and Paradigm Shifts. 71st Annual Meeting of the Society of Biological Psychiatry

Abstract


  • The postmortem human brain is a valuable resource for

    examining the biological basis of severe psychiatric disorders

    such as schizophrenia and bipolar disorder. Postmortem

    studies provide a snapshot of the biochemical and molecular

    processes occurring in the brain under pathological

    conditions, which can be problematic to otherwise model due

    to their polygenic aetiologies. In the last decade, the

    neuroscience field has largely shifted towards mainstream

    use of several new experimental techniques with

    unprecedented accuracy, the ability to extricate minute

    details and generate large amounts of data from small

    amounts of sample. Applications of these techniques are

    revolutionizing the field of postmortem brain research by

    dramatically improving the way postmortem tissues are being

    studied and integrated with other evidence from

    neuroscience. The aim of this symposium is to convincingly

    convey this paradigm shift in human postmortem brain

    research. The works described by all our speakers showcase

    new techniques at the forefront of psychiatric neuroscience

    that have advanced the way we use postmortem tissues to

    identify molecular and neuroanatomical alterations that

    contribute to the manifestation of severe psychiatric

    conditions. As postmortem studies are especially valuable for

    directing and prioritizing future in vitro or in vivo

    experimental work, this symposium will be relevant to a wide audience outside of the postmortem research field. Focusing

    on new technologies, better scientific processes and paradigm

    shifts in psychiatry will not only consolidate and realign the

    postmortem research field, but provide a highly informed

    symposium which will ultimately improve our understanding

    of severe psychiatric conditions.

Publication Date


  • 2016

Citation


  • Matosin, N. & Meador-Woodruff, J. H. (2016). Harnessing the Postmortem Human Brain to Study Severe Psychiatric Disorders: Methodological Innovations and Paradigm Shifts. 71st Annual Meeting of the Society of Biological Psychiatry