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Problematic eating behaviours, changes in appetite, and weight gain in Major Depressive Disorder: The role of leptin

Journal Article


Abstract


  • Background: Appetite and weight changes are core symptoms of Major Depressive Disorder (MDD), and those

    with MDD are at increased risk of obesity, cardiovascular disease and metabolic disorders. Leptin promotes

    satiety, with leptin dysregulation and resistance noted in obesity. However, the role of leptin in weight changes

    in MDD is not established. This study investigates leptin levels in relation to appetite and weight changes and

    problematic eating behaviours in MDD.

    Methods: Plasma leptin levels, psychopathology and biometrics were compared between participants meeting

    DSM-5 diagnostic criteria for MDD (n = 63) and healthy controls (n = 60). Depressed participants were also subcategorised

    according to increased, decreased or unchanged appetite and weight. The Dutch Eating Behaviour

    Questionnaire and Yale Food Addiction Scale were examined in a subset of participants with MDD.

    Results: Females with increased appetite/weight had higher leptin levels than those with stable or reduced

    appetite/weight, however males showed the opposite effect. Leptin levels were positively correlated with problematic

    eating behaviours. One quarter of the depressed subset, all females, met the Yale criteria for food

    addiction, approximately double the rates reported in general community samples.

    Limitations: The study is limited by a cross sectional design and a small sample size in the subset analysis of

    eating behaviours.

    Conclusions: The results provide new information about associations between leptin, sex-specific weight and

    appetite changes and problematic eating behaviours, which may be risk factors for cardiovascular and metabolic

    diseases in MDD, particularly in females. Future longitudinal research investigating leptin as a risk factor for

    weight gain in MDD is warranted, and may lead to early interventions aimed at preventing weight gain in at-risk

    individuals.

Publication Date


  • 2018

Citation


  • Mills, J. G., Thomas, S. J., Larkin, T. A., Pai, N. B. & Deng, C. (2018). Problematic eating behaviours, changes in appetite, and weight gain in Major Depressive Disorder: The role of leptin. Journal of Affective Disorders, 240 137-145.

Scopus Eid


  • 2-s2.0-85050671510

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/103

Number Of Pages


  • 8

Start Page


  • 137

End Page


  • 145

Volume


  • 240

Place Of Publication


  • Netherlands

Abstract


  • Background: Appetite and weight changes are core symptoms of Major Depressive Disorder (MDD), and those

    with MDD are at increased risk of obesity, cardiovascular disease and metabolic disorders. Leptin promotes

    satiety, with leptin dysregulation and resistance noted in obesity. However, the role of leptin in weight changes

    in MDD is not established. This study investigates leptin levels in relation to appetite and weight changes and

    problematic eating behaviours in MDD.

    Methods: Plasma leptin levels, psychopathology and biometrics were compared between participants meeting

    DSM-5 diagnostic criteria for MDD (n = 63) and healthy controls (n = 60). Depressed participants were also subcategorised

    according to increased, decreased or unchanged appetite and weight. The Dutch Eating Behaviour

    Questionnaire and Yale Food Addiction Scale were examined in a subset of participants with MDD.

    Results: Females with increased appetite/weight had higher leptin levels than those with stable or reduced

    appetite/weight, however males showed the opposite effect. Leptin levels were positively correlated with problematic

    eating behaviours. One quarter of the depressed subset, all females, met the Yale criteria for food

    addiction, approximately double the rates reported in general community samples.

    Limitations: The study is limited by a cross sectional design and a small sample size in the subset analysis of

    eating behaviours.

    Conclusions: The results provide new information about associations between leptin, sex-specific weight and

    appetite changes and problematic eating behaviours, which may be risk factors for cardiovascular and metabolic

    diseases in MDD, particularly in females. Future longitudinal research investigating leptin as a risk factor for

    weight gain in MDD is warranted, and may lead to early interventions aimed at preventing weight gain in at-risk

    individuals.

Publication Date


  • 2018

Citation


  • Mills, J. G., Thomas, S. J., Larkin, T. A., Pai, N. B. & Deng, C. (2018). Problematic eating behaviours, changes in appetite, and weight gain in Major Depressive Disorder: The role of leptin. Journal of Affective Disorders, 240 137-145.

Scopus Eid


  • 2-s2.0-85050671510

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/103

Number Of Pages


  • 8

Start Page


  • 137

End Page


  • 145

Volume


  • 240

Place Of Publication


  • Netherlands