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Interactions of early-life stress with the genome and epigenome: from prenatal stress to psychiatric disorders

Journal Article


Abstract


  • Adverse life events, especially early in life, have consistently been shown to strongly increase risk for psychiatric disorders like mood and anxiety disorders as well as psychoses. Both prenatal and postnatal stressors have been shown to have a long-lasting impact on adult psychopathology, and the type and timing of the stressors are important moderators of response severity. This is consistent with literature showing that during early development both prenatally and postnatally, the brain responds strongly to environmental cues while undergoing extensive dynamic changes. This review will highlight early life adversity and gene × early life adversity interactions that can have long-lasting effects on mental health. A main focus will be the role of epigenetics, especially DNA methylation, in mediating these lasting effects on the organism.

Authors


  •   Cruceanu, Cristiana (external author)
  •   Matosin, Natalie
  •   Binder, Elisabeth B. (external author)

Publication Date


  • 2017

Citation


  • Cruceanu, C., Matosin, N. & Binder, E. B. (2017). Interactions of early-life stress with the genome and epigenome: from prenatal stress to psychiatric disorders. Current Opinion in Behavioral Sciences, 14 167-171.

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/173

Number Of Pages


  • 4

Start Page


  • 167

End Page


  • 171

Volume


  • 14

Place Of Publication


  • Netherlands

Abstract


  • Adverse life events, especially early in life, have consistently been shown to strongly increase risk for psychiatric disorders like mood and anxiety disorders as well as psychoses. Both prenatal and postnatal stressors have been shown to have a long-lasting impact on adult psychopathology, and the type and timing of the stressors are important moderators of response severity. This is consistent with literature showing that during early development both prenatally and postnatally, the brain responds strongly to environmental cues while undergoing extensive dynamic changes. This review will highlight early life adversity and gene × early life adversity interactions that can have long-lasting effects on mental health. A main focus will be the role of epigenetics, especially DNA methylation, in mediating these lasting effects on the organism.

Authors


  •   Cruceanu, Cristiana (external author)
  •   Matosin, Natalie
  •   Binder, Elisabeth B. (external author)

Publication Date


  • 2017

Citation


  • Cruceanu, C., Matosin, N. & Binder, E. B. (2017). Interactions of early-life stress with the genome and epigenome: from prenatal stress to psychiatric disorders. Current Opinion in Behavioral Sciences, 14 167-171.

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/173

Number Of Pages


  • 4

Start Page


  • 167

End Page


  • 171

Volume


  • 14

Place Of Publication


  • Netherlands