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Acute high-intensity interval exercise reduces human monocyte Toll-like receptor 2 expression in type 2 diabetes

Journal Article


Abstract


  • Acute highintensity

    interval exercise reduces human monocyte Toll-like receptor

    2 expression in type 2 diabetes. Am J Physiol Regul Integr Comp

    Physiol 312: R529 –R538, 2017. First published January 25, 2017;

    doi:10.1152/ajpregu.00348.2016.—Type 2 diabetes (T2D) is characterized

    by chronic low-grade inflammation that contributes to disease

    pathophysiology. Exercise has anti-inflammatory effects, but the impact

    of high-intensity interval training (HIIT) is not known. The

    purpose of this study was to determine the impact of a single session

    of HIIT on cellular, molecular, and circulating markers of inflammation

    in individuals with T2D. Participants with T2D (n 10) and

    healthy age-matched controls (HC; n 9) completed an acute bout of

    HIIT (7 1 min at ~85% maximal aerobic power output, separated by

    1 min of recovery) on a cycle ergometer with blood samples obtained

    before (Pre), immediately after (Post), and at 1 h of recovery (1-h

    Post). Inflammatory markers on leukocytes were measured by flow

    cytometry, and TNF- was assessed in both LPS-stimulated whole

    blood cultures and plasma. A single session of HIIT had an overall

    anti-inflammatory effect, as evidenced by 1) significantly lower levels

    of Toll-like receptor (TLR) 2 surface protein expression on both

    classical and CD16 monocytes assessed at Post and 1-h Post

    compared with Pre (P 0.05 for all); 2) significantly lower LPSstimulated

    TNF- release in whole blood cultures at 1-h Post (P

    0.05 vs. Pre); and 3) significantly lower levels of plasma TNF- at 1-h

    Post (P 0.05 vs. Pre). There were no differences between T2D and

    HC, except for a larger decrease in plasma TNF- in HC vs. T2D

    (group time interaction, P 0.05). One session of low-volume

    HIIT has immunomodulatory effects and provides potential antiinflammatory

    benefits to people with, and without, T2D.

Authors


  •   Durrer, Cody (external author)
  •   Dr Monique Francois
  •   Neudorf, Helena (external author)
  •   Little, Jonathan P. (external author)

Publication Date


  • 2017

Geographic Focus


Citation


  • Durrer, C., Francois, M., Neudorf, H. & Little, J. P. (2017). Acute high-intensity interval exercise reduces human monocyte Toll-like receptor 2 expression in type 2 diabetes. American journal of physiology regulatory integrative and comparative physiology, 312 R529-R538.

Scopus Eid


  • 2-s2.0-85016972185

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/72

Start Page


  • R529

End Page


  • R538

Volume


  • 312

Place Of Publication


  • United States

Abstract


  • Acute highintensity

    interval exercise reduces human monocyte Toll-like receptor

    2 expression in type 2 diabetes. Am J Physiol Regul Integr Comp

    Physiol 312: R529 –R538, 2017. First published January 25, 2017;

    doi:10.1152/ajpregu.00348.2016.—Type 2 diabetes (T2D) is characterized

    by chronic low-grade inflammation that contributes to disease

    pathophysiology. Exercise has anti-inflammatory effects, but the impact

    of high-intensity interval training (HIIT) is not known. The

    purpose of this study was to determine the impact of a single session

    of HIIT on cellular, molecular, and circulating markers of inflammation

    in individuals with T2D. Participants with T2D (n 10) and

    healthy age-matched controls (HC; n 9) completed an acute bout of

    HIIT (7 1 min at ~85% maximal aerobic power output, separated by

    1 min of recovery) on a cycle ergometer with blood samples obtained

    before (Pre), immediately after (Post), and at 1 h of recovery (1-h

    Post). Inflammatory markers on leukocytes were measured by flow

    cytometry, and TNF- was assessed in both LPS-stimulated whole

    blood cultures and plasma. A single session of HIIT had an overall

    anti-inflammatory effect, as evidenced by 1) significantly lower levels

    of Toll-like receptor (TLR) 2 surface protein expression on both

    classical and CD16 monocytes assessed at Post and 1-h Post

    compared with Pre (P 0.05 for all); 2) significantly lower LPSstimulated

    TNF- release in whole blood cultures at 1-h Post (P

    0.05 vs. Pre); and 3) significantly lower levels of plasma TNF- at 1-h

    Post (P 0.05 vs. Pre). There were no differences between T2D and

    HC, except for a larger decrease in plasma TNF- in HC vs. T2D

    (group time interaction, P 0.05). One session of low-volume

    HIIT has immunomodulatory effects and provides potential antiinflammatory

    benefits to people with, and without, T2D.

Authors


  •   Durrer, Cody (external author)
  •   Dr Monique Francois
  •   Neudorf, Helena (external author)
  •   Little, Jonathan P. (external author)

Publication Date


  • 2017

Geographic Focus


Citation


  • Durrer, C., Francois, M., Neudorf, H. & Little, J. P. (2017). Acute high-intensity interval exercise reduces human monocyte Toll-like receptor 2 expression in type 2 diabetes. American journal of physiology regulatory integrative and comparative physiology, 312 R529-R538.

Scopus Eid


  • 2-s2.0-85016972185

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/72

Start Page


  • R529

End Page


  • R538

Volume


  • 312

Place Of Publication


  • United States