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Combining short-term interval training with caloric restriction improves ß-cell function in obese adults

Journal Article


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Abstract


  • Although low-calorie diets (LCD) improve glucose regulation, it is unclear if interval exercise (INT) is additive. We examined the impact of an LCD versus LCD + INT training on ß-cell function in relation to glucose tolerance in obese adults. Twenty-six adults (Age: 46 ± 12 year; BMI 38 ± 6 kg/m2) were randomized to 2-week of LCD (~1200 kcal/day) or energy-matched LCD + INT (60 min/day alternating 3 min at 90 and 50% HRpeak). A 2 h 75 g oral glucose tolerance test (OGTT) was performed. Insulin secretion rates (ISR) were determined by deconvolution modeling to assess glucose-stimulated insulin secretion ([GSIS: ISR/glucose total area under the curve (tAUC)]) and ß-cell function (Disposition Index [DI: GSIS/IR]) relative to skeletal muscle (Matsuda Index), hepatic (HOMA-IR) and adipose (Adipose-IRfasting) insulin resistance (IR). LCD + INT, but not LCD alone, reduced glucose and total-phase ISR tAUC (Interactions: p = 0.04 and p = 0.05, respectively). Both interventions improved skeletal muscle IR by 16% (p = 0.04) and skeletal muscle and hepatic DI (Time: p < 0.05). Improved skeletal muscle DI was associated with lower glucose tAUC (r = −0.57, p < 0.01). Thus, LCD + INT improved glucose tolerance more than LCD in obese adults, and these findings relate to ß-cell function. These data support LCD + INT for preserving pancreatic function for type 2 diabetes prevention.

Authors


  •   Dr Monique Francois
  •   Gilbertson, Nicole (external author)
  •   Eichner, Natalie (external author)
  •   Heiston, Emily (external author)
  •   Fabris, Chiara (external author)
  •   Breton, Marc (external author)
  •   Mehaffey, J (external author)
  •   Hassinger, Taryn (external author)
  •   Hallowell, Peter (external author)
  •   Malin, Steven (external author)

Publication Date


  • 2018

Citation


  • Francois, M. E., Gilbertson, N. M., Eichner, N. Z. M., Heiston, E. M., Fabris, C., Breton, M., Mehaffey, J. Hunter., Hassinger, T., Hallowell, P. T. & Malin, S. K. (2018). Combining short-term interval training with caloric restriction improves ß-cell function in obese adults. Nutrients, 10 (6), 717-1-717-13.

Scopus Eid


  • 2-s2.0-85048057334

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1061&context=smhpapers1

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/61

Start Page


  • 717-1

End Page


  • 717-13

Volume


  • 10

Issue


  • 6

Place Of Publication


  • Switzerland

Abstract


  • Although low-calorie diets (LCD) improve glucose regulation, it is unclear if interval exercise (INT) is additive. We examined the impact of an LCD versus LCD + INT training on ß-cell function in relation to glucose tolerance in obese adults. Twenty-six adults (Age: 46 ± 12 year; BMI 38 ± 6 kg/m2) were randomized to 2-week of LCD (~1200 kcal/day) or energy-matched LCD + INT (60 min/day alternating 3 min at 90 and 50% HRpeak). A 2 h 75 g oral glucose tolerance test (OGTT) was performed. Insulin secretion rates (ISR) were determined by deconvolution modeling to assess glucose-stimulated insulin secretion ([GSIS: ISR/glucose total area under the curve (tAUC)]) and ß-cell function (Disposition Index [DI: GSIS/IR]) relative to skeletal muscle (Matsuda Index), hepatic (HOMA-IR) and adipose (Adipose-IRfasting) insulin resistance (IR). LCD + INT, but not LCD alone, reduced glucose and total-phase ISR tAUC (Interactions: p = 0.04 and p = 0.05, respectively). Both interventions improved skeletal muscle IR by 16% (p = 0.04) and skeletal muscle and hepatic DI (Time: p < 0.05). Improved skeletal muscle DI was associated with lower glucose tAUC (r = −0.57, p < 0.01). Thus, LCD + INT improved glucose tolerance more than LCD in obese adults, and these findings relate to ß-cell function. These data support LCD + INT for preserving pancreatic function for type 2 diabetes prevention.

Authors


  •   Dr Monique Francois
  •   Gilbertson, Nicole (external author)
  •   Eichner, Natalie (external author)
  •   Heiston, Emily (external author)
  •   Fabris, Chiara (external author)
  •   Breton, Marc (external author)
  •   Mehaffey, J (external author)
  •   Hassinger, Taryn (external author)
  •   Hallowell, Peter (external author)
  •   Malin, Steven (external author)

Publication Date


  • 2018

Citation


  • Francois, M. E., Gilbertson, N. M., Eichner, N. Z. M., Heiston, E. M., Fabris, C., Breton, M., Mehaffey, J. Hunter., Hassinger, T., Hallowell, P. T. & Malin, S. K. (2018). Combining short-term interval training with caloric restriction improves ß-cell function in obese adults. Nutrients, 10 (6), 717-1-717-13.

Scopus Eid


  • 2-s2.0-85048057334

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1061&context=smhpapers1

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/61

Start Page


  • 717-1

End Page


  • 717-13

Volume


  • 10

Issue


  • 6

Place Of Publication


  • Switzerland