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Nanoparticles for super-resolution microscopy and single-molecule tracking

Journal Article


Abstract


  • We review the use of luminescent nanoparticles in super-resolution imaging and single-molecule tracking, and showcase novel approaches to super-resolution imaging that leverage the brightness, stability, and unique optical-switching properties of these nanoparticles. We also discuss the challenges associated with their use in biological systems, including intracellular delivery and molecular targeting. In doing so, we hope to provide practical guidance for biologists and continue to bridge the fields of super-resolution imaging and nanoparticle engineering to support their mutual advancement.

Authors


  •   Jin, Dayong (external author)
  •   Xi, Peng (external author)
  •   Wang, Baoming (external author)
  •   Zhang, Le (external author)
  •   Enderlein, Jorg (external author)
  •   van Oijen, Antoine M.

Publication Date


  • 2018

Citation


  • Jin, D., Xi, P., Wang, B., Zhang, L., Enderlein, J. & van Oijen, A. M. (2018). Nanoparticles for super-resolution microscopy and single-molecule tracking. Nature Methods, 15 415-423.

Scopus Eid


  • 2-s2.0-85047818082

Number Of Pages


  • 8

Start Page


  • 415

End Page


  • 423

Volume


  • 15

Place Of Publication


  • United Kingdom

Abstract


  • We review the use of luminescent nanoparticles in super-resolution imaging and single-molecule tracking, and showcase novel approaches to super-resolution imaging that leverage the brightness, stability, and unique optical-switching properties of these nanoparticles. We also discuss the challenges associated with their use in biological systems, including intracellular delivery and molecular targeting. In doing so, we hope to provide practical guidance for biologists and continue to bridge the fields of super-resolution imaging and nanoparticle engineering to support their mutual advancement.

Authors


  •   Jin, Dayong (external author)
  •   Xi, Peng (external author)
  •   Wang, Baoming (external author)
  •   Zhang, Le (external author)
  •   Enderlein, Jorg (external author)
  •   van Oijen, Antoine M.

Publication Date


  • 2018

Citation


  • Jin, D., Xi, P., Wang, B., Zhang, L., Enderlein, J. & van Oijen, A. M. (2018). Nanoparticles for super-resolution microscopy and single-molecule tracking. Nature Methods, 15 415-423.

Scopus Eid


  • 2-s2.0-85047818082

Number Of Pages


  • 8

Start Page


  • 415

End Page


  • 423

Volume


  • 15

Place Of Publication


  • United Kingdom