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Considerations to facilitate a US study that replicates PREDIMED

Journal Article


Abstract


  • The PREDIMED clinical trial provided strong evidence that a Mediterranean dietary pattern (MedDiet) could help prevent cardiovascular disease (CVD) events in high risk middle-aged/older people. This report considers the feasibility of replicating PREDIMED in the U.S., including recommendations for dietary and behavioral principles. A 14-point Mediterranean diet Adherence Score (MEDAS) guided the PREDIMED MedDiet recommendations. At baseline MEDAS points were ~8.5. During intervention this score increased to nearly 11 in MedDiet vs. 9 in control. In the MedDiet groups, only about 0.5 points of the net 2 point MEDAS increase was attributable to the gratis supplements of olive oil or nuts. An issue in a U.S. replication is the large difference in typical U.S. versus Spanish diet and lifestyle. A typical U.S. diet would achieve a MEDAS of 1–2. A replication is scientifically feasible with an assumption such as that the MedDiet reflects a continuum of specific food choices and meal patterns. As such, a 2 point change in MEDAS at any point on the continuum would be hypothesized to reduce incident CVD. A conservative approach would aim for a randomized 4 point MEDAS difference, e.g. 5–6 points vs. an average U.S. diet group that achieved only 1–2 points.

UOW Authors


  •   Jacobs Jr, David R. (external author)
  •   Petersen, Kristina (external author)
  •   Svendsen, Karianne (external author)
  •   Ros, Emilio (external author)
  •   Sloan, Carol (external author)
  •   Steffen, Lyn (external author)
  •   Tapsell, Linda
  •   Kris-Etherton, Penny (external author)

Publication Date


  • 2018

Citation


  • Jacobs Jr, D. R., Petersen, K. S., Svendsen, K., Ros, E., Sloan, C. B., Steffen, L. M., Tapsell, L. C. & Kris-Etherton, P. M. (2018). Considerations to facilitate a US study that replicates PREDIMED. Metabolism: clinical and experimental, 85 361-367.

Scopus Eid


  • 2-s2.0-85046842536

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/57

Number Of Pages


  • 6

Start Page


  • 361

End Page


  • 367

Volume


  • 85

Place Of Publication


  • United States

Abstract


  • The PREDIMED clinical trial provided strong evidence that a Mediterranean dietary pattern (MedDiet) could help prevent cardiovascular disease (CVD) events in high risk middle-aged/older people. This report considers the feasibility of replicating PREDIMED in the U.S., including recommendations for dietary and behavioral principles. A 14-point Mediterranean diet Adherence Score (MEDAS) guided the PREDIMED MedDiet recommendations. At baseline MEDAS points were ~8.5. During intervention this score increased to nearly 11 in MedDiet vs. 9 in control. In the MedDiet groups, only about 0.5 points of the net 2 point MEDAS increase was attributable to the gratis supplements of olive oil or nuts. An issue in a U.S. replication is the large difference in typical U.S. versus Spanish diet and lifestyle. A typical U.S. diet would achieve a MEDAS of 1–2. A replication is scientifically feasible with an assumption such as that the MedDiet reflects a continuum of specific food choices and meal patterns. As such, a 2 point change in MEDAS at any point on the continuum would be hypothesized to reduce incident CVD. A conservative approach would aim for a randomized 4 point MEDAS difference, e.g. 5–6 points vs. an average U.S. diet group that achieved only 1–2 points.

UOW Authors


  •   Jacobs Jr, David R. (external author)
  •   Petersen, Kristina (external author)
  •   Svendsen, Karianne (external author)
  •   Ros, Emilio (external author)
  •   Sloan, Carol (external author)
  •   Steffen, Lyn (external author)
  •   Tapsell, Linda
  •   Kris-Etherton, Penny (external author)

Publication Date


  • 2018

Citation


  • Jacobs Jr, D. R., Petersen, K. S., Svendsen, K., Ros, E., Sloan, C. B., Steffen, L. M., Tapsell, L. C. & Kris-Etherton, P. M. (2018). Considerations to facilitate a US study that replicates PREDIMED. Metabolism: clinical and experimental, 85 361-367.

Scopus Eid


  • 2-s2.0-85046842536

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers1/57

Number Of Pages


  • 6

Start Page


  • 361

End Page


  • 367

Volume


  • 85

Place Of Publication


  • United States