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Prognostic significance of blood transfusion and anaemia on survival in stage IIIA/B/C and IVA oesophageal cancers treated with chemoradiotherapy

Journal Article


Abstract


  • Objective

    To evaluate the prognostic effect of blood transfusion (BT) on survival outcomes in patients with stage IIIA/B/C and IVA oesophageal cancers treated with induction chemotherapy and chemoradiotherapy (C → CRT).

    Methods

    The medical records of patients with oesophageal cancer treated with C → CRT at the Royal Marsden Hospital, U.K. between 2000 and 2007 were identified and reviewed retrospectively. Patients had weekly haemoglobin measurements and received BT to maintain haemoglobin at the level of 12 g/dL and above as per the institutional policy. Overall survival (OS), progression-free survival (PFS) and locoregional recurrence-free survival (LRFS) were estimated by the Kaplan-Meier method. Cox proportional hazards regression models were used to determine the effect of anaemic and transfusion status on survival outcomes after adjusting for selected prognostic characteristics.

    Results

    Among 151 stage IIIA/B/C and IVA patients, the two-year rates for OS (53 and 53 vs. 27 %), PFS (36 and 29 vs. 22 %) and LRFS (57 and 59 vs. 43 %) were higher in those who were not anaemic and those who were anaemic with transfusion vs. those who were anaemic without transfusion, respectively. At multivariate analysis, anaemic patients who received blood transfusion had significantly lower risk of death (hazard ratios (HR) = 0.41, 95 % CI 0.23–0.74, p = 0.003), progression (HR = 0.46, 95 % CI 0.25–0.84, p = 0.009) and locoregional relapse (HR = 0.38, 95 % CI 0.16–0.89, p = 0.025) vs. those who did not.

    Conclusion

    With these current data, there was a significant benefit of BT in stage IIIA/B/C and IVA oesophageal cancers treated with chemoradiation.

UOW Authors


  •   Tuan, Jeffrey Kit Loong (external author)
  •   Ha, Tam
  •   Pan, Summer (external author)
  •   Hawkins, Maria (external author)
  •   Tait, Diana (external author)

Publication Date


  • 2014

Citation


  • Tuan, J., Ha, T. C., Pan, S., Hawkins, M. & Tait, D. (2014). Prognostic significance of blood transfusion and anaemia on survival in stage IIIA/B/C and IVA oesophageal cancers treated with chemoradiotherapy. Journal of Radiation Oncology, 3 (2), 167-177.

Ro Metadata Url


  • http://ro.uow.edu.au/sspapers/3613

Number Of Pages


  • 10

Start Page


  • 167

End Page


  • 177

Volume


  • 3

Issue


  • 2

Place Of Publication


  • Germany

Abstract


  • Objective

    To evaluate the prognostic effect of blood transfusion (BT) on survival outcomes in patients with stage IIIA/B/C and IVA oesophageal cancers treated with induction chemotherapy and chemoradiotherapy (C → CRT).

    Methods

    The medical records of patients with oesophageal cancer treated with C → CRT at the Royal Marsden Hospital, U.K. between 2000 and 2007 were identified and reviewed retrospectively. Patients had weekly haemoglobin measurements and received BT to maintain haemoglobin at the level of 12 g/dL and above as per the institutional policy. Overall survival (OS), progression-free survival (PFS) and locoregional recurrence-free survival (LRFS) were estimated by the Kaplan-Meier method. Cox proportional hazards regression models were used to determine the effect of anaemic and transfusion status on survival outcomes after adjusting for selected prognostic characteristics.

    Results

    Among 151 stage IIIA/B/C and IVA patients, the two-year rates for OS (53 and 53 vs. 27 %), PFS (36 and 29 vs. 22 %) and LRFS (57 and 59 vs. 43 %) were higher in those who were not anaemic and those who were anaemic with transfusion vs. those who were anaemic without transfusion, respectively. At multivariate analysis, anaemic patients who received blood transfusion had significantly lower risk of death (hazard ratios (HR) = 0.41, 95 % CI 0.23–0.74, p = 0.003), progression (HR = 0.46, 95 % CI 0.25–0.84, p = 0.009) and locoregional relapse (HR = 0.38, 95 % CI 0.16–0.89, p = 0.025) vs. those who did not.

    Conclusion

    With these current data, there was a significant benefit of BT in stage IIIA/B/C and IVA oesophageal cancers treated with chemoradiation.

UOW Authors


  •   Tuan, Jeffrey Kit Loong (external author)
  •   Ha, Tam
  •   Pan, Summer (external author)
  •   Hawkins, Maria (external author)
  •   Tait, Diana (external author)

Publication Date


  • 2014

Citation


  • Tuan, J., Ha, T. C., Pan, S., Hawkins, M. & Tait, D. (2014). Prognostic significance of blood transfusion and anaemia on survival in stage IIIA/B/C and IVA oesophageal cancers treated with chemoradiotherapy. Journal of Radiation Oncology, 3 (2), 167-177.

Ro Metadata Url


  • http://ro.uow.edu.au/sspapers/3613

Number Of Pages


  • 10

Start Page


  • 167

End Page


  • 177

Volume


  • 3

Issue


  • 2

Place Of Publication


  • Germany