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The neural correlates of alcohol-related aggression

Journal Article


Abstract


  • © 2018, Psychonomic Society, Inc. Alcohol intoxication is implicated in approximately half of all violent crimes. Over the past several decades, numerous theories have been proposed to account for the influence of alcohol on aggression. Nearly all of these theories imply that altered functioning in the prefrontal cortex is a proximal cause. In the present functional magnetic resonance imaging (fMRI) experiment, 50 healthy young men consumed either a low dose of alcohol or a placebo and completed an aggression paradigm against provocative and nonprovocative opponents. Provocation did not affect neural responses. However, relative to sober participants, during acts of aggression, intoxicated participants showed decreased activity in the prefrontal cortex, caudate, and ventral striatum, but heightened activation in the hippocampus. Among intoxicated participants, but not among sober participants, aggressive behavior was positively correlated with activation in the medial and dorsolateral prefrontal cortex. These results support theories that posit a role for prefrontal cortical dysfunction as an important factor in intoxicated aggression.

Authors


  •   Denson, Thomas F. (external author)
  •   Blundell, Kate (external author)
  •   Schofield, Timothy (external author)
  •   Schira, Mark M.
  •   Kramer, Ulrike (external author)

Publication Date


  • 2018

Citation


  • Denson, T., Blundell, K., Schofield, T., Schira, M. & Kramer, U. (2018). The neural correlates of alcohol-related aggression. Cognitive, Affective and Behavioral Neuroscience, 18 (2), 203-215.

Scopus Eid


  • 2-s2.0-85045038547

Ro Metadata Url


  • http://ro.uow.edu.au/sspapers/3647

Number Of Pages


  • 12

Start Page


  • 203

End Page


  • 215

Volume


  • 18

Issue


  • 2

Place Of Publication


  • United States

Abstract


  • © 2018, Psychonomic Society, Inc. Alcohol intoxication is implicated in approximately half of all violent crimes. Over the past several decades, numerous theories have been proposed to account for the influence of alcohol on aggression. Nearly all of these theories imply that altered functioning in the prefrontal cortex is a proximal cause. In the present functional magnetic resonance imaging (fMRI) experiment, 50 healthy young men consumed either a low dose of alcohol or a placebo and completed an aggression paradigm against provocative and nonprovocative opponents. Provocation did not affect neural responses. However, relative to sober participants, during acts of aggression, intoxicated participants showed decreased activity in the prefrontal cortex, caudate, and ventral striatum, but heightened activation in the hippocampus. Among intoxicated participants, but not among sober participants, aggressive behavior was positively correlated with activation in the medial and dorsolateral prefrontal cortex. These results support theories that posit a role for prefrontal cortical dysfunction as an important factor in intoxicated aggression.

Authors


  •   Denson, Thomas F. (external author)
  •   Blundell, Kate (external author)
  •   Schofield, Timothy (external author)
  •   Schira, Mark M.
  •   Kramer, Ulrike (external author)

Publication Date


  • 2018

Citation


  • Denson, T., Blundell, K., Schofield, T., Schira, M. & Kramer, U. (2018). The neural correlates of alcohol-related aggression. Cognitive, Affective and Behavioral Neuroscience, 18 (2), 203-215.

Scopus Eid


  • 2-s2.0-85045038547

Ro Metadata Url


  • http://ro.uow.edu.au/sspapers/3647

Number Of Pages


  • 12

Start Page


  • 203

End Page


  • 215

Volume


  • 18

Issue


  • 2

Place Of Publication


  • United States