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Graphene foam as a biocompatible scaffold for culturing human neurons

Journal Article


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Abstract


  • In this study, we explore the use of electrically active graphene foam as a scaffold for the culture of human-derived neurons. Human embryonic stem cell (hESC)-derived cortical neurons fated as either glutamatergic or GABAergic neuronal phenotypes were cultured on graphene foam. We show that graphene foam is biocompatible for the culture of human neurons, capable of supporting cell viability and differentiation of hESC-derived cortical neurons. Based on the findings, we propose that graphene foam represents a suitable scaffold for engineering neuronal tissue and warrants further investigation as a model for understanding neuronal maturation, function and circuit formation.

Authors


  •   D'Abaco, Giovanna (external author)
  •   Mattei, Cristiana (external author)
  •   Nasr, Babak (external author)
  •   Hudson, Emma J. (external author)
  •   Alshawaf, Abdullah (external author)
  •   Chana, Gursharan (external author)
  •   Everall, Ian (external author)
  •   Nayagam, Bryony A. (external author)
  •   Dottori, Mirella
  •   Skafidas, Efstratios (external author)

Publication Date


  • 2018

Citation


  • D'Abaco, G. M., Mattei, C., Nasr, B., Hudson, E. J., Alshawaf, A. J., Chana, G., Everall, I. P., Nayagam, B., Dottori, M. & Skafidas, E. (2018). Graphene foam as a biocompatible scaffold for culturing human neurons. Royal Society Open Science, 5 (3), 171364-1-171364-11.

Scopus Eid


  • 2-s2.0-85043569366

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2246&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/1219

Start Page


  • 171364-1

End Page


  • 171364-11

Volume


  • 5

Issue


  • 3

Place Of Publication


  • United Kingdom

Abstract


  • In this study, we explore the use of electrically active graphene foam as a scaffold for the culture of human-derived neurons. Human embryonic stem cell (hESC)-derived cortical neurons fated as either glutamatergic or GABAergic neuronal phenotypes were cultured on graphene foam. We show that graphene foam is biocompatible for the culture of human neurons, capable of supporting cell viability and differentiation of hESC-derived cortical neurons. Based on the findings, we propose that graphene foam represents a suitable scaffold for engineering neuronal tissue and warrants further investigation as a model for understanding neuronal maturation, function and circuit formation.

Authors


  •   D'Abaco, Giovanna (external author)
  •   Mattei, Cristiana (external author)
  •   Nasr, Babak (external author)
  •   Hudson, Emma J. (external author)
  •   Alshawaf, Abdullah (external author)
  •   Chana, Gursharan (external author)
  •   Everall, Ian (external author)
  •   Nayagam, Bryony A. (external author)
  •   Dottori, Mirella
  •   Skafidas, Efstratios (external author)

Publication Date


  • 2018

Citation


  • D'Abaco, G. M., Mattei, C., Nasr, B., Hudson, E. J., Alshawaf, A. J., Chana, G., Everall, I. P., Nayagam, B., Dottori, M. & Skafidas, E. (2018). Graphene foam as a biocompatible scaffold for culturing human neurons. Royal Society Open Science, 5 (3), 171364-1-171364-11.

Scopus Eid


  • 2-s2.0-85043569366

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2246&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/1219

Start Page


  • 171364-1

End Page


  • 171364-11

Volume


  • 5

Issue


  • 3

Place Of Publication


  • United Kingdom