Clozapine is underutilized and many psychiatrists tend to avoid clozapine and instead use non-evidence based
treatments. Despite 3 decades since the publication of Clozapine Treatment resistant study, there is a reason to think
that at least some of the 12 post - clozapine drugs could be effective across the gradient of treatment resistance.
Clinical experience suggest low discontinuation rates with clozapine treatment and that continuing clozapine
treatment is associated with real-world improvements in functional and clinical outcomes. However there are ongoing
debates related to definition of treatment resistance, earlier use of clozapine, weighing benefit vs risk related to
choice of clozapine, usefulness of clozapine in cognitive functions and overall quality of life, clozapine's efficacy and
effectiveness might diminish as it is used later in the illness etc.,ln addition this presentation tries to address what
clinicians are to make of all this, in terms of selecting an antipsychotic drug for their patients?