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Rational antipsychotic use and the clozapine story

Conference Paper


Abstract


  • Clozapine is underutilized and many psychiatrists tend to avoid clozapine and instead use non-evidence based

    treatments. Despite 3 decades since the publication of Clozapine Treatment resistant study, there is a reason to think

    that at least some of the 12 post - clozapine drugs could be effective across the gradient of treatment resistance.

    Clinical experience suggest low discontinuation rates with clozapine treatment and that continuing clozapine

    treatment is associated with real-world improvements in functional and clinical outcomes. However there are ongoing

    debates related to definition of treatment resistance, earlier use of clozapine, weighing benefit vs risk related to

    choice of clozapine, usefulness of clozapine in cognitive functions and overall quality of life, clozapine's efficacy and

    effectiveness might diminish as it is used later in the illness etc.,ln addition this presentation tries to address what

    clinicians are to make of all this, in terms of selecting an antipsychotic drug for their patients?

Publication Date


  • 2018

Citation


  • Pai, N. (2018). Rational antipsychotic use and the clozapine story. WPA thematic Congress Innovation in psychiatry: Effective interventions for health and Society (pp. 1-1).

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End Page


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Abstract


  • Clozapine is underutilized and many psychiatrists tend to avoid clozapine and instead use non-evidence based

    treatments. Despite 3 decades since the publication of Clozapine Treatment resistant study, there is a reason to think

    that at least some of the 12 post - clozapine drugs could be effective across the gradient of treatment resistance.

    Clinical experience suggest low discontinuation rates with clozapine treatment and that continuing clozapine

    treatment is associated with real-world improvements in functional and clinical outcomes. However there are ongoing

    debates related to definition of treatment resistance, earlier use of clozapine, weighing benefit vs risk related to

    choice of clozapine, usefulness of clozapine in cognitive functions and overall quality of life, clozapine's efficacy and

    effectiveness might diminish as it is used later in the illness etc.,ln addition this presentation tries to address what

    clinicians are to make of all this, in terms of selecting an antipsychotic drug for their patients?

Publication Date


  • 2018

Citation


  • Pai, N. (2018). Rational antipsychotic use and the clozapine story. WPA thematic Congress Innovation in psychiatry: Effective interventions for health and Society (pp. 1-1).

Start Page


  • 1

End Page


  • 1