Skip to main content
placeholder image

Does body mass index and adult height influence cancer incidence among Chinese living with incident type 2 diabetes?

Journal Article


Abstract


  • Background: We investigated the site-specific cancer incidence risks among participants living with newly diagnosed type 2 diabetes (T2D) in relation to body mass index (BMI) and height. Methods: The sample consisted of 25,130 participants living in Ningbo (China) who were newly diagnosed with T2D between 01/01/2006 and 12/31/2007 but without cardiovascular disease or cancer diagnoses at baseline. Follow-up of the sample was from 01/01/2008 to 12/31/2014. Cancer incidence stratified by BMI categories and quartiles of height were analyzed using standardized incidence ratios (SIR; the ratio of observed to the expected number of diagnosed cases) with 95% confidence intervals (95%CI). Results: Follow-up included 22,795 participants, 155,845 person-years and 1063 cancer diagnoses. Compared with the general population of Ningbo, SIRs of all-cancer were 2.19 (95% CI: 2.01–2.37) for males and 1.80 (95% CI: 1.64–1.96) for females. The all-cancer SIRs for participants in the normal BMI category was 1.13 (95% CI: 1.00–1.38). By comparison, the SIRs for the overweight and obese groups were 0.62 (95% CI: 0.26–0.95) and 0.35 (95% CI: 0.03–0.71), respectively. Besides, higher participants had higher all-cancer SIRs. For males, SIRs were 1.08 (95% CI: 0.88–1.27) and 2.41 (95% CI: 2.05–2.78) in the lowest and highest quartiles of height, respectively. For females, SIRs were 1.03 (95% CI: 0.72–1.35) and 2.01 (95% CI: 1.66–2.58) in the lowest and highest quartiles of height, respectively. Conclusion: In this sample of participants living with newly diagnosed T2D, cancer incidence was higher among those who were taller, but also lower among those with higher BMI.

Authors


  •   Duan, Donghui (external author)
  •   Xu, Jiaying (external author)
  •   Feng, Xiaoqi
  •   Astell-Burt, Thomas E.
  •   Xu, Guodong (external author)
  •   Lu, Nanjia (external author)
  •   Li, Hui (external author)
  •   Xu, Guozhang (external author)
  •   Han, Liyuan (external author)

Publication Date


  • 2018

Citation


  • Duan, D., Xu, J., Feng, X., Astell-Burt, T., Xu, G., Lu, N., Li, H., Xu, G. & Han, L. (2018). Does body mass index and adult height influence cancer incidence among Chinese living with incident type 2 diabetes?. Cancer Epidemiology: the international journal of cancer epidemiology, detection and prevention, 53 187-194.

Scopus Eid


  • 2-s2.0-85042797399

Ro Metadata Url


  • http://ro.uow.edu.au/sspapers/3467

Number Of Pages


  • 7

Start Page


  • 187

End Page


  • 194

Volume


  • 53

Place Of Publication


  • United States

Abstract


  • Background: We investigated the site-specific cancer incidence risks among participants living with newly diagnosed type 2 diabetes (T2D) in relation to body mass index (BMI) and height. Methods: The sample consisted of 25,130 participants living in Ningbo (China) who were newly diagnosed with T2D between 01/01/2006 and 12/31/2007 but without cardiovascular disease or cancer diagnoses at baseline. Follow-up of the sample was from 01/01/2008 to 12/31/2014. Cancer incidence stratified by BMI categories and quartiles of height were analyzed using standardized incidence ratios (SIR; the ratio of observed to the expected number of diagnosed cases) with 95% confidence intervals (95%CI). Results: Follow-up included 22,795 participants, 155,845 person-years and 1063 cancer diagnoses. Compared with the general population of Ningbo, SIRs of all-cancer were 2.19 (95% CI: 2.01–2.37) for males and 1.80 (95% CI: 1.64–1.96) for females. The all-cancer SIRs for participants in the normal BMI category was 1.13 (95% CI: 1.00–1.38). By comparison, the SIRs for the overweight and obese groups were 0.62 (95% CI: 0.26–0.95) and 0.35 (95% CI: 0.03–0.71), respectively. Besides, higher participants had higher all-cancer SIRs. For males, SIRs were 1.08 (95% CI: 0.88–1.27) and 2.41 (95% CI: 2.05–2.78) in the lowest and highest quartiles of height, respectively. For females, SIRs were 1.03 (95% CI: 0.72–1.35) and 2.01 (95% CI: 1.66–2.58) in the lowest and highest quartiles of height, respectively. Conclusion: In this sample of participants living with newly diagnosed T2D, cancer incidence was higher among those who were taller, but also lower among those with higher BMI.

Authors


  •   Duan, Donghui (external author)
  •   Xu, Jiaying (external author)
  •   Feng, Xiaoqi
  •   Astell-Burt, Thomas E.
  •   Xu, Guodong (external author)
  •   Lu, Nanjia (external author)
  •   Li, Hui (external author)
  •   Xu, Guozhang (external author)
  •   Han, Liyuan (external author)

Publication Date


  • 2018

Citation


  • Duan, D., Xu, J., Feng, X., Astell-Burt, T., Xu, G., Lu, N., Li, H., Xu, G. & Han, L. (2018). Does body mass index and adult height influence cancer incidence among Chinese living with incident type 2 diabetes?. Cancer Epidemiology: the international journal of cancer epidemiology, detection and prevention, 53 187-194.

Scopus Eid


  • 2-s2.0-85042797399

Ro Metadata Url


  • http://ro.uow.edu.au/sspapers/3467

Number Of Pages


  • 7

Start Page


  • 187

End Page


  • 194

Volume


  • 53

Place Of Publication


  • United States