The effects of temperature, pressure, initial promoter concentration and coal seam gas/liquid ratio on the separation of methane from coal seam gas were experimentally investigated. Low temperature, high pressure and high promoter concentration lead to high separation efficiency and high recovery rate of CH 4 , but reduce the CH 4 capture selectivity in hydrate. Experimental simulation of a three-stage separation shows that CH 4 can be concentrated from 34.6 to 81.3 mol% in the dissociated gas, while its content is only 7.2 mol% in the residual gas. An innovative model was established to predict the separation performance. The modeling results reasonably match the experimental data in predicting the effects of different influential factors, with an average relative deviation of 2.83%, the maximum relative deviation 11.2%, and the average relative variance 0.1044. The modeling results of a three-stage separation process include 81.0 mol% of CH 4 in the final dissociated gas and 5.5 mol% of CH 4 in the final residual gas. The recovery rate of CH 4 was 90.1 mol% and the separation factor was 73.0.