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Three-dimensional neural cultures produce networks that mimic native brain activity

Journal Article


Abstract


  • Development of brain function is critically dependent on neuronal networks organized through three dimensions. Culture of central nervous system neurons has traditionally been limited to two dimensions, restricting growth patterns and network formation to a single plane. Here, with the use of multichannel extracellular microelectrode arrays, we demonstrate that neurons cultured in a true three-dimensional environment recapitulate native neuronal network formation and produce functional outcomes more akin to in vivo neuronal network activity.

Publication Date


  • 2018

Citation


  • Bourke, J. L., Quigley, A. F., Duchi, S., O'Connell, C. D., Crook, J. M., Wallace, G. G., Cook, M. J. & Kapsa, R. (2018). Three-dimensional neural cultures produce networks that mimic native brain activity. Journal of Tissue Engineering and Regenerative Medicine, 12 (2), 490-493.

Scopus Eid


  • 2-s2.0-85042125118

Number Of Pages


  • 3

Start Page


  • 490

End Page


  • 493

Volume


  • 12

Issue


  • 2

Place Of Publication


  • United States

Abstract


  • Development of brain function is critically dependent on neuronal networks organized through three dimensions. Culture of central nervous system neurons has traditionally been limited to two dimensions, restricting growth patterns and network formation to a single plane. Here, with the use of multichannel extracellular microelectrode arrays, we demonstrate that neurons cultured in a true three-dimensional environment recapitulate native neuronal network formation and produce functional outcomes more akin to in vivo neuronal network activity.

Publication Date


  • 2018

Citation


  • Bourke, J. L., Quigley, A. F., Duchi, S., O'Connell, C. D., Crook, J. M., Wallace, G. G., Cook, M. J. & Kapsa, R. (2018). Three-dimensional neural cultures produce networks that mimic native brain activity. Journal of Tissue Engineering and Regenerative Medicine, 12 (2), 490-493.

Scopus Eid


  • 2-s2.0-85042125118

Number Of Pages


  • 3

Start Page


  • 490

End Page


  • 493

Volume


  • 12

Issue


  • 2

Place Of Publication


  • United States