Skip to main content
placeholder image

Endogenous testosterone and cortisol modulate neural responses during induced anger control

Journal Article


Abstract


  • Research with violent offenders and delinquent adolescents suggests that endogenous testosterone concentrations have the strongest positive correlations with violence among men who have low concentrations of cortisol. The present study tested the hypothesis that testosterone and cortisol would similarly interact to determine neural activation in regions supporting self-regulation in response to anger provocation. Nineteen healthy Asian male participants were insulted and asked to control their anger during functional magnetic resonance imaging (fMRI). When cortisol levels were low, testosterone positively correlated with activation in the dorsolateral prefrontal cortex (dlPFC) and thalamus, but not when cortisol levels were high. During induced anger control, functional connectivity was increased between the amygdala and a top-down prefrontal cortical control network. Moreover, the amygdala-PFC connectivity was strongest among those high in testosterone and low in cortisol. This research highlights a possible neural mechanism by which testosterone and cortisol may influence anger control.

UOW Authors


  •   Denson, Thomas F. (external author)
  •   Ronay, Richard (external author)
  •   Von Hippel, W (external author)
  •   Schira, Mark

Publication Date


  • 2013

Citation


  • Denson, T. F., Ronay, R., von Hippel, W. & Schira, M. M. (2013). Endogenous testosterone and cortisol modulate neural responses during induced anger control. Social Neuroscience, 8 (2), 165-177.

Scopus Eid


  • 2-s2.0-84874181085

Has Global Citation Frequency


Number Of Pages


  • 12

Start Page


  • 165

End Page


  • 177

Volume


  • 8

Issue


  • 2

Place Of Publication


  • United Kingdom

Abstract


  • Research with violent offenders and delinquent adolescents suggests that endogenous testosterone concentrations have the strongest positive correlations with violence among men who have low concentrations of cortisol. The present study tested the hypothesis that testosterone and cortisol would similarly interact to determine neural activation in regions supporting self-regulation in response to anger provocation. Nineteen healthy Asian male participants were insulted and asked to control their anger during functional magnetic resonance imaging (fMRI). When cortisol levels were low, testosterone positively correlated with activation in the dorsolateral prefrontal cortex (dlPFC) and thalamus, but not when cortisol levels were high. During induced anger control, functional connectivity was increased between the amygdala and a top-down prefrontal cortical control network. Moreover, the amygdala-PFC connectivity was strongest among those high in testosterone and low in cortisol. This research highlights a possible neural mechanism by which testosterone and cortisol may influence anger control.

UOW Authors


  •   Denson, Thomas F. (external author)
  •   Ronay, Richard (external author)
  •   Von Hippel, W (external author)
  •   Schira, Mark

Publication Date


  • 2013

Citation


  • Denson, T. F., Ronay, R., von Hippel, W. & Schira, M. M. (2013). Endogenous testosterone and cortisol modulate neural responses during induced anger control. Social Neuroscience, 8 (2), 165-177.

Scopus Eid


  • 2-s2.0-84874181085

Has Global Citation Frequency


Number Of Pages


  • 12

Start Page


  • 165

End Page


  • 177

Volume


  • 8

Issue


  • 2

Place Of Publication


  • United Kingdom