The concept of person-centred practice provides nurses with a framework for undertsanding the complexity of the health-care setting. It is applicable across differing care contexts (from acute care to rehabilitation to care within the home), and flexible enough to take into account the needs of patients of all ages. At its heart is the need for those who work in such contexts to focus on delivery of care that achieves outcomes that benefit the patient, their family and themselves. Providing such care not only nurtures the patient and supports the family, but also ensures staff invest in creating care cultures that result in improved well-being for all. The creation of effective person-centred cultures is neither easy or straightforward; it requires a common vision and goals, strategic planning, systematic approaches, supportive leadership, tenacity and dedication. In this chapter we will be sharing with you how one organsiation has developed Person-Centred Paediatric Practice as the foundation for nursing.