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Acetylcholinesterase inhibitory activity of chemical constituents isolated from Miliusa thorelii

Journal Article


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Abstract


  • Two new dihydrooxoprotoberberine alkaloids; miliusathorines A (1) and B (2), a new natural flavone, miliusathorone (3), together with twenty-two known compounds (4–25) were isolated from the combined stem and root extract and the leaf extract of Miliusa thorelii. The structures of all isolated compounds were elucidated by spectroscopic methods and mass spectrometry. All compounds were evaluated for their acetylcholinesterase activities. Miliusathorine A (1) and norushisunine had the best AChE inhibitory activities, however these were weak inhibitors when compared to the standard galantamine.

UOW Authors


  •   Promchai, Thanika (external author)
  •   Saesong, Tongchai (external author)
  •   Ingkaninan, Kornkanok (external author)
  •   Laphookhieo, Surat (external author)
  •   Pyne, Stephen
  •   Ritthiwigrom, Thunwadee (external author)

Publication Date


  • 2018

Citation


  • Promchai, T., Saesong, T., Ingkaninan, K., Laphookhieo, S., Pyne, S. G. & Limtharakul, T. (2018). Acetylcholinesterase inhibitory activity of chemical constituents isolated from Miliusa thorelii. Phytochemistry Letters, 23 33-37.

Scopus Eid


  • 2-s2.0-85033601611

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=6102&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/5050

Number Of Pages


  • 4

Start Page


  • 33

End Page


  • 37

Volume


  • 23

Place Of Publication


  • Netherlands

Abstract


  • Two new dihydrooxoprotoberberine alkaloids; miliusathorines A (1) and B (2), a new natural flavone, miliusathorone (3), together with twenty-two known compounds (4–25) were isolated from the combined stem and root extract and the leaf extract of Miliusa thorelii. The structures of all isolated compounds were elucidated by spectroscopic methods and mass spectrometry. All compounds were evaluated for their acetylcholinesterase activities. Miliusathorine A (1) and norushisunine had the best AChE inhibitory activities, however these were weak inhibitors when compared to the standard galantamine.

UOW Authors


  •   Promchai, Thanika (external author)
  •   Saesong, Tongchai (external author)
  •   Ingkaninan, Kornkanok (external author)
  •   Laphookhieo, Surat (external author)
  •   Pyne, Stephen
  •   Ritthiwigrom, Thunwadee (external author)

Publication Date


  • 2018

Citation


  • Promchai, T., Saesong, T., Ingkaninan, K., Laphookhieo, S., Pyne, S. G. & Limtharakul, T. (2018). Acetylcholinesterase inhibitory activity of chemical constituents isolated from Miliusa thorelii. Phytochemistry Letters, 23 33-37.

Scopus Eid


  • 2-s2.0-85033601611

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=6102&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/5050

Number Of Pages


  • 4

Start Page


  • 33

End Page


  • 37

Volume


  • 23

Place Of Publication


  • Netherlands