Skip to main content
placeholder image

Continuous transformation of chiral pharmaceuticals in enzymatic membrane bioreactors for advanced wastewater treatment

Journal Article


Download full-text (Open Access)

Abstract


  • This study demonstrates continuous enantiomeric inversion and further biotransformation of chiral profens including ibuprofen, naproxen and ketoprofen by an enzymatic membrane bioreactor (EMBR) dosed with laccase. The EMBR showed non-enantioselective transformations, with high and consistent transformation of both (R)- and (S)-ibuprofen (93 ± 6%, n = 10), but lower removals of both enantiomers of naproxen (46 ± 16%, n = 10) and ketoprofen (48 ± 17%, n = 10). Enantiomeric analysis revealed a bidirectional but uneven inversion of the profens, for example 14% inversion of (R)- to (S)- compared to 4% from (S)- to (R)-naproxen. With redox-mediator addition, the enzymatic chiral inversion of both (R)- and (S)-profens remained unchanged, although the overall conversion became enantioselective; except for (S)-naproxen, the addition of redox mediator promoted the degradation of (R)-profens only.

Authors


  •   Nguyen, Luong (external author)
  •   Hai, Faisal I.
  •   McDonald, James A. (external author)
  •   Khan, Stuart J. (external author)
  •   Price, William E.
  •   Nghiem, Long D. (external author)

Publication Date


  • 2017

Citation


  • Nguyen, L. N., Hai, F. I., McDonald, J. A., Khan, S. J., Price, W. E. & Nghiem, L. D. (2017). Continuous transformation of chiral pharmaceuticals in enzymatic membrane bioreactors for advanced wastewater treatment. Water Science and Technology, 76 (7), 1816-1826.

Scopus Eid


  • 2-s2.0-85030860081

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1828&context=eispapers1

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers1/827

Number Of Pages


  • 10

Start Page


  • 1816

End Page


  • 1826

Volume


  • 76

Issue


  • 7

Place Of Publication


  • United Kingdom

Abstract


  • This study demonstrates continuous enantiomeric inversion and further biotransformation of chiral profens including ibuprofen, naproxen and ketoprofen by an enzymatic membrane bioreactor (EMBR) dosed with laccase. The EMBR showed non-enantioselective transformations, with high and consistent transformation of both (R)- and (S)-ibuprofen (93 ± 6%, n = 10), but lower removals of both enantiomers of naproxen (46 ± 16%, n = 10) and ketoprofen (48 ± 17%, n = 10). Enantiomeric analysis revealed a bidirectional but uneven inversion of the profens, for example 14% inversion of (R)- to (S)- compared to 4% from (S)- to (R)-naproxen. With redox-mediator addition, the enzymatic chiral inversion of both (R)- and (S)-profens remained unchanged, although the overall conversion became enantioselective; except for (S)-naproxen, the addition of redox mediator promoted the degradation of (R)-profens only.

Authors


  •   Nguyen, Luong (external author)
  •   Hai, Faisal I.
  •   McDonald, James A. (external author)
  •   Khan, Stuart J. (external author)
  •   Price, William E.
  •   Nghiem, Long D. (external author)

Publication Date


  • 2017

Citation


  • Nguyen, L. N., Hai, F. I., McDonald, J. A., Khan, S. J., Price, W. E. & Nghiem, L. D. (2017). Continuous transformation of chiral pharmaceuticals in enzymatic membrane bioreactors for advanced wastewater treatment. Water Science and Technology, 76 (7), 1816-1826.

Scopus Eid


  • 2-s2.0-85030860081

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1828&context=eispapers1

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers1/827

Number Of Pages


  • 10

Start Page


  • 1816

End Page


  • 1826

Volume


  • 76

Issue


  • 7

Place Of Publication


  • United Kingdom