A highly sensitive sensor is strategically designed for bisphenol A (BPA) detection. To enable the sensor to meet the requirements of sensitivity and selectivity, dendritic platinum nanoparticles (DPNs) with a high surface area were prepared and directly coated on gold nanoparticles deposited on a screen-printed carbon electrode, followed by the deposition of a polyethyleneimine-phosphatidylcholine (PEI-PC) layer. The PEI-PC layer protects the sensor against interference effects (such as from ascorbic acid, acetaminophen, uric acid, and dopamine) and further enhances the sensitivity. With our sensor, we were able to detect the presence of bisphenol A precisely at the oxidation potential of 0.270. V. The sensor performance in BPA detection using amperometry under the optimized experimental conditions was demonstrated to reveal the two wide dynamic ranges of 0.01-1.0. μM and 1.0. μM-300. μM, with correlation coefficients of 0.9957 and 0.9864, respectively. The detection limit (DL) for BPA was determined to be 6.63. ±. 0.77. nM. To examine its reliability, the sensor was evaluated for the detection of BPA in tap water through a recovery study, which paves the way for practical applications.