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Dietary teasaponin ameliorates alteration of gut microbiota and cognitive decline in diet-induced obese mice

Journal Article


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Abstract


  • A high-fat (HF) diet alters gut microbiota and promotes obesity related infammation and cognitive

    impairment. Teasaponin is the major active component of tea, and has been associated with antiinfammatory efects and improved microbiota composition. However, the potential protective

    efects of teasaponin, against HF diet-induced obesity and its associated alteration of gut microbiota,

    infammation and cognitive decline have not been studied. In this study, obesity was induced in

    C57BL/6J male mice by feeding a HF diet for 8 weeks, followed by treatment with oral teasaponin

    (0.5%) mixed in HF diet for a further 6 weeks. Teasaponin treatment prevented the HF diet-induced

    recognition memory impairment and improved neuroinfammation, gliosis and brain-derived

    neurotrophic factor (BDNF) defcits in the hippocampus. Furthermore, teasaponin attenuated the

    HF diet-induced endotoxemia, pro-infammatory macrophage accumulation in the colon and gut

    microbiota alterations. Teasaponin also improved glucose tolerance and reduced body weight gain in

    HF diet-induced obese mice. The behavioral and neurochemical improvements suggest that teasaponin could limit unfavorable gut microbiota alterations and cognitive decline in HF diet-induced obesity.

Publication Date


  • 2017

Citation


  • Wang, S., Huang, X., Zhang, P., Newell, K. A., Wang, H., Zheng, K. & Yu, Y. (2017). Dietary teasaponin ameliorates alteration of gut microbiota and cognitive decline in diet-induced obese mice. Scientific Reports, 7 12203 -1-12203 -13.

Scopus Eid


  • 2-s2.0-85029763414

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2156&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/1130

Has Global Citation Frequency


Start Page


  • 12203 -1

End Page


  • 12203 -13

Volume


  • 7

Place Of Publication


  • United Kingdom

Abstract


  • A high-fat (HF) diet alters gut microbiota and promotes obesity related infammation and cognitive

    impairment. Teasaponin is the major active component of tea, and has been associated with antiinfammatory efects and improved microbiota composition. However, the potential protective

    efects of teasaponin, against HF diet-induced obesity and its associated alteration of gut microbiota,

    infammation and cognitive decline have not been studied. In this study, obesity was induced in

    C57BL/6J male mice by feeding a HF diet for 8 weeks, followed by treatment with oral teasaponin

    (0.5%) mixed in HF diet for a further 6 weeks. Teasaponin treatment prevented the HF diet-induced

    recognition memory impairment and improved neuroinfammation, gliosis and brain-derived

    neurotrophic factor (BDNF) defcits in the hippocampus. Furthermore, teasaponin attenuated the

    HF diet-induced endotoxemia, pro-infammatory macrophage accumulation in the colon and gut

    microbiota alterations. Teasaponin also improved glucose tolerance and reduced body weight gain in

    HF diet-induced obese mice. The behavioral and neurochemical improvements suggest that teasaponin could limit unfavorable gut microbiota alterations and cognitive decline in HF diet-induced obesity.

Publication Date


  • 2017

Citation


  • Wang, S., Huang, X., Zhang, P., Newell, K. A., Wang, H., Zheng, K. & Yu, Y. (2017). Dietary teasaponin ameliorates alteration of gut microbiota and cognitive decline in diet-induced obese mice. Scientific Reports, 7 12203 -1-12203 -13.

Scopus Eid


  • 2-s2.0-85029763414

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2156&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/1130

Has Global Citation Frequency


Start Page


  • 12203 -1

End Page


  • 12203 -13

Volume


  • 7

Place Of Publication


  • United Kingdom