Skip to main content
placeholder image

Modelling interaction between a methane molecule and biological channels

Journal Article


Abstract


  • Aquaporins are small ubiquitous membranes in biological channels that play significant role in the transportation of nano-sized materials, such as water and other biomolecules, into cell. The present work proposes a mathematical model to determine the potential energy of the interaction between a methane molecule and three different types of aquaporin channels, which are aquaporin-Z, aquaglyceroporin and aquaporin-1. We adopt a continuous model, where all atoms comprising the aquaporin channels are assumed to be uniformly distributed throughout their volumes. We also assume that a methane molecule comprises two parts: A single point representing the carbon atom at the centre and a spherical shell of four evenly distributed hydrogen atoms. Our results indicate the naturalistic acceptance of a methane molecule inside aquaglyceroporin and aquaporin-1 channels, but the repulsion occurs for the case of aquaporin-Z channel.

UOW Authors


  •   Al Garalleh, Hakim Abdul (external author)
  •   Thamwattana, Natalie
  •   Garaleh, Mazen (external author)

Publication Date


  • 2017

Citation


  • Al Garalleh, H., Thamwattana, N. & Garaleh, M. (2017). Modelling interaction between a methane molecule and biological channels. Journal of Computational and Theoretical Nanoscience, 14 (7), 3416-3421.

Scopus Eid


  • 2-s2.0-85027450565

Number Of Pages


  • 5

Start Page


  • 3416

End Page


  • 3421

Volume


  • 14

Issue


  • 7

Place Of Publication


  • United States

Abstract


  • Aquaporins are small ubiquitous membranes in biological channels that play significant role in the transportation of nano-sized materials, such as water and other biomolecules, into cell. The present work proposes a mathematical model to determine the potential energy of the interaction between a methane molecule and three different types of aquaporin channels, which are aquaporin-Z, aquaglyceroporin and aquaporin-1. We adopt a continuous model, where all atoms comprising the aquaporin channels are assumed to be uniformly distributed throughout their volumes. We also assume that a methane molecule comprises two parts: A single point representing the carbon atom at the centre and a spherical shell of four evenly distributed hydrogen atoms. Our results indicate the naturalistic acceptance of a methane molecule inside aquaglyceroporin and aquaporin-1 channels, but the repulsion occurs for the case of aquaporin-Z channel.

UOW Authors


  •   Al Garalleh, Hakim Abdul (external author)
  •   Thamwattana, Natalie
  •   Garaleh, Mazen (external author)

Publication Date


  • 2017

Citation


  • Al Garalleh, H., Thamwattana, N. & Garaleh, M. (2017). Modelling interaction between a methane molecule and biological channels. Journal of Computational and Theoretical Nanoscience, 14 (7), 3416-3421.

Scopus Eid


  • 2-s2.0-85027450565

Number Of Pages


  • 5

Start Page


  • 3416

End Page


  • 3421

Volume


  • 14

Issue


  • 7

Place Of Publication


  • United States