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Mechanochemical synthesis of chitosan submicron particles from the gladius of Todarodes pacificus

Journal Article


Abstract


  • The present work focused on the synthesis of β-chitosan submicron particles (CSPs) from Todarodes pacificus using mechanochemical techniques. The gladius was submitted to a sequence of mechanical and chemical treatments to synthesize β-chitin (CT), which was further deacetylated to form spherical chitosan submicron particles with an average diameter of ⩽100 nm. The surface morphology of β-chitin and CSPs was observed using electron microscopy. The degree of deacetylation (DD%), evaluated from the absorbance peak of a Fourier Transform Infrared (FTIR) spectrum, was 80 ± 2.5%. Physicochemical characterization exhibited good crystallinity, positive zeta potential and low molecular weight, as well as reduced ash content and high water-binding capacity. CSPs exhibit significant antimicrobial properties toward all tested pathogenic bacterial and fungal microorganisms. Antioxidant analysis revealed high reducing power and excellent scavenging and chelating ability. Hence, CSPs synthesized from gladius of Todarodes pacificus using mechanochemical techniques are promising candidates for biomedical applications.

UOW Authors


  •   Anusha, J R. (external author)
  •   Fleming, Albin T. (external author)
  •   Valan Arasu, M (external author)
  •   Kim, Byung Chul. (external author)
  •   Al-Dhabi, Naif (external author)
  •   Yu, Kook Hyun (external author)
  •   Raj, C Justin. (external author)

Publication Date


  • 2016

Citation


  • Anusha, J. R., Fleming, A. T., Valan Arasu, M., Kim, B. Chul., Al-Dhabi, N. Abdullah., Yu, K. & Raj, C. Justin. (2016). Mechanochemical synthesis of chitosan submicron particles from the gladius of Todarodes pacificus. Journal of Advanced Research, 7 (6), 863-871.

Scopus Eid


  • 2-s2.0-84987984810

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/2678

Number Of Pages


  • 8

Start Page


  • 863

End Page


  • 871

Volume


  • 7

Issue


  • 6

Place Of Publication


  • Netherlands

Abstract


  • The present work focused on the synthesis of β-chitosan submicron particles (CSPs) from Todarodes pacificus using mechanochemical techniques. The gladius was submitted to a sequence of mechanical and chemical treatments to synthesize β-chitin (CT), which was further deacetylated to form spherical chitosan submicron particles with an average diameter of ⩽100 nm. The surface morphology of β-chitin and CSPs was observed using electron microscopy. The degree of deacetylation (DD%), evaluated from the absorbance peak of a Fourier Transform Infrared (FTIR) spectrum, was 80 ± 2.5%. Physicochemical characterization exhibited good crystallinity, positive zeta potential and low molecular weight, as well as reduced ash content and high water-binding capacity. CSPs exhibit significant antimicrobial properties toward all tested pathogenic bacterial and fungal microorganisms. Antioxidant analysis revealed high reducing power and excellent scavenging and chelating ability. Hence, CSPs synthesized from gladius of Todarodes pacificus using mechanochemical techniques are promising candidates for biomedical applications.

UOW Authors


  •   Anusha, J R. (external author)
  •   Fleming, Albin T. (external author)
  •   Valan Arasu, M (external author)
  •   Kim, Byung Chul. (external author)
  •   Al-Dhabi, Naif (external author)
  •   Yu, Kook Hyun (external author)
  •   Raj, C Justin. (external author)

Publication Date


  • 2016

Citation


  • Anusha, J. R., Fleming, A. T., Valan Arasu, M., Kim, B. Chul., Al-Dhabi, N. Abdullah., Yu, K. & Raj, C. Justin. (2016). Mechanochemical synthesis of chitosan submicron particles from the gladius of Todarodes pacificus. Journal of Advanced Research, 7 (6), 863-871.

Scopus Eid


  • 2-s2.0-84987984810

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/2678

Number Of Pages


  • 8

Start Page


  • 863

End Page


  • 871

Volume


  • 7

Issue


  • 6

Place Of Publication


  • Netherlands