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Antioxidant, Cytotoxic and α-Glucosidase Inhibitory Activities of Compounds isolated from the Twig Extracts of Maclura fruticosa

Journal Article


Abstract


  • The first phytochemical investigation of the twig extracts of Maclura fruticosa led to the isolation and identification of a new xanthone, maclurafruticosone (1), together with 14 known compounds (2-15). All compounds were elucidated using spectroscopic methods as well as through comparisons made with data reported in the literature. Some isolated compounds were evaluated for their antioxidant, α-glucosidase inhibitory and cytotoxic activities. Compound 4, 6 and 7 showed significant antioxidant activity against DPPH radicals with IC50 values ranging from 7.45–16.12 μM. Compound 4 also exhibited potent activity against ABTS•+ scavenging activity with an IC50 value of 0.55 ± 0.01 μM which was better than positive control (ascorbic acid, IC50 2.35 ± 0.17 μM). Compound 12 showed significant α-glucosidase inhibitory activity with an IC50 value of 0.02 ± 0.37 mM. Compounds 5, 6 and 12 showed weak cytotoxic activities against a colon cancer cell line with IC50 values ranging from 22.35–47.62 μM.

UOW Authors


  •   Polbuppha, Isaraporn (external author)
  •   Maneerat, Wisanu (external author)
  •   Sripisut, Tawanun (external author)
  •   Ritthiwigrom, Thunwadee (external author)
  •   Cheenpracha, Sarot (external author)
  •   Pyne, Stephen
  •   Muanprasat, Chatchai (external author)
  •   Seemakhan, Sawinee (external author)
  •   Borwornpinyo, Suparerk (external author)
  •   Laphookhieo, Surat (external author)

Publication Date


  • 2017

Citation


  • Polbuppha, I., Maneerat, W., Sripisut, T., Ritthiwigrom, T., Cheenpracha, S., Pyne, S. G., Muanprasat, C., Seemakhan, S., Borwornpinyo, S. & Laphookhieo, S. (2017). Antioxidant, Cytotoxic and α-Glucosidase Inhibitory Activities of Compounds isolated from the Twig Extracts of Maclura fruticosa. Natural Product Communications: an international journal for communications and reviews, 12 (7), 1073-1076.

Number Of Pages


  • 3

Start Page


  • 1073

End Page


  • 1076

Volume


  • 12

Issue


  • 7

Place Of Publication


  • United States

Abstract


  • The first phytochemical investigation of the twig extracts of Maclura fruticosa led to the isolation and identification of a new xanthone, maclurafruticosone (1), together with 14 known compounds (2-15). All compounds were elucidated using spectroscopic methods as well as through comparisons made with data reported in the literature. Some isolated compounds were evaluated for their antioxidant, α-glucosidase inhibitory and cytotoxic activities. Compound 4, 6 and 7 showed significant antioxidant activity against DPPH radicals with IC50 values ranging from 7.45–16.12 μM. Compound 4 also exhibited potent activity against ABTS•+ scavenging activity with an IC50 value of 0.55 ± 0.01 μM which was better than positive control (ascorbic acid, IC50 2.35 ± 0.17 μM). Compound 12 showed significant α-glucosidase inhibitory activity with an IC50 value of 0.02 ± 0.37 mM. Compounds 5, 6 and 12 showed weak cytotoxic activities against a colon cancer cell line with IC50 values ranging from 22.35–47.62 μM.

UOW Authors


  •   Polbuppha, Isaraporn (external author)
  •   Maneerat, Wisanu (external author)
  •   Sripisut, Tawanun (external author)
  •   Ritthiwigrom, Thunwadee (external author)
  •   Cheenpracha, Sarot (external author)
  •   Pyne, Stephen
  •   Muanprasat, Chatchai (external author)
  •   Seemakhan, Sawinee (external author)
  •   Borwornpinyo, Suparerk (external author)
  •   Laphookhieo, Surat (external author)

Publication Date


  • 2017

Citation


  • Polbuppha, I., Maneerat, W., Sripisut, T., Ritthiwigrom, T., Cheenpracha, S., Pyne, S. G., Muanprasat, C., Seemakhan, S., Borwornpinyo, S. & Laphookhieo, S. (2017). Antioxidant, Cytotoxic and α-Glucosidase Inhibitory Activities of Compounds isolated from the Twig Extracts of Maclura fruticosa. Natural Product Communications: an international journal for communications and reviews, 12 (7), 1073-1076.

Number Of Pages


  • 3

Start Page


  • 1073

End Page


  • 1076

Volume


  • 12

Issue


  • 7

Place Of Publication


  • United States