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In vitro investigation of the dose-rate effect on the biological effectiveness of megavoltage X-ray radiation doses

Journal Article


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Abstract

  • Radiation therapy is rapidly evolving toward the delivery of higher dose rates to improve cancer treatment. In vitro experiments were performed to investigate the response of 9L and MCF-7 cancer cell lines, exposed to 10 MV X-ray radiations. Up to 8 Gy was delivered at a dose-rate of 50 cGy/min compared to 5 Gy/min. The data obtained emphasizes the importance of taking into account not only the physical, but also the radiobiological parameters, when planning a particular cancer treatment.

UOW Authors

  •   Oktaria, Sianne (external author)
  •   Lerch, Michael L. F. (external author)
  •   Rozenfeld, Anatoly
  •   Tehei, Moeava (external author)
  •   Corde, Stephanie B. (external author)

Publication Date

  • 2017

Citation

  • Oktaria, S., Lerch, M. L. F., Rosenfeld, A. B., Tehei, M. & Corde, S. (2017). In vitro investigation of the dose-rate effect on the biological effectiveness of megavoltage X-ray radiation doses. Applied Radiation and Isotopes, 128 114-119.

Scopus Eid

  • 2-s2.0-85022226476

Ro Full-text Url

  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1456&context=eispapers1

Ro Metadata Url

  • http://ro.uow.edu.au/eispapers1/455

Number Of Pages

  • 5

Start Page

  • 114

End Page

  • 119

Volume

  • 128

Place Of Publication

  • United Kingdom

Abstract

  • Radiation therapy is rapidly evolving toward the delivery of higher dose rates to improve cancer treatment. In vitro experiments were performed to investigate the response of 9L and MCF-7 cancer cell lines, exposed to 10 MV X-ray radiations. Up to 8 Gy was delivered at a dose-rate of 50 cGy/min compared to 5 Gy/min. The data obtained emphasizes the importance of taking into account not only the physical, but also the radiobiological parameters, when planning a particular cancer treatment.

UOW Authors

  •   Oktaria, Sianne (external author)
  •   Lerch, Michael L. F. (external author)
  •   Rozenfeld, Anatoly
  •   Tehei, Moeava (external author)
  •   Corde, Stephanie B. (external author)

Publication Date

  • 2017

Citation

  • Oktaria, S., Lerch, M. L. F., Rosenfeld, A. B., Tehei, M. & Corde, S. (2017). In vitro investigation of the dose-rate effect on the biological effectiveness of megavoltage X-ray radiation doses. Applied Radiation and Isotopes, 128 114-119.

Scopus Eid

  • 2-s2.0-85022226476

Ro Full-text Url

  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1456&context=eispapers1

Ro Metadata Url

  • http://ro.uow.edu.au/eispapers1/455

Number Of Pages

  • 5

Start Page

  • 114

End Page

  • 119

Volume

  • 128

Place Of Publication

  • United Kingdom