An increased prevalence of chronic disease and an ageing population is threatening to challenge the way we deliver healthcare. Despite the growth of nursing in general practice, it is predicted that general practitioners and nurses will struggle to meet the growing demand for primary care services. Previous research however, has shown that collaboration between health professionals can improve efficiencies and health outcomes. Given the largely private nature of general practice, it is not known if these findings can be extrapolated to this setting. This study, therefore, seeks to explore the factors which influence collaboration in this unique healthcare setting.