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Intake of 7,8-dihydroxyflavone from pregnancy to weaning prevents cognitive deficits in adult offspring after maternal immune activation

Journal Article


Abstract


  • Brain-derived neurotrophic factor (BDNF) and its high-affinity receptor, tropomyosin receptor kinase B (TrkB) signaling plays a key role in the brain neurodevelopment. The exposure of pregnant mice to polyinosinic¿polycytidylic acid [poly(I:C)] causes cognitive deficits in adult offspring. Supplementation with a TrkB agonist, 7,8-dihydroxyflavone, in poly(I:C)-treated pregnant mice from pregnancy to weaning could prevent the onset of cognitive deficits and reduced BDNF¿TrkB signaling in the prefrontal cortex of their adult offspring. These findings suggest that supplementation with a TrkB agonist in pregnant women with an ultra-high risk of psychosis may reduce the development of psychosis in their offspring.

Authors


Publication Date


  • 2017

Citation


  • Han, M., Zhang, J., Huang, X. & Hashimoto, K. (2017). Intake of 7,8-dihydroxyflavone from pregnancy to weaning prevents cognitive deficits in adult offspring after maternal immune activation. European Archives of Psychiatry and Clinical Neuroscience: official organ of the German society for biological psychiatry, 267 (5), 479-483.

Scopus Eid


  • 2-s2.0-85017511452

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/1057

Has Global Citation Frequency


Number Of Pages


  • 4

Start Page


  • 479

End Page


  • 483

Volume


  • 267

Issue


  • 5

Place Of Publication


  • Germany

Abstract


  • Brain-derived neurotrophic factor (BDNF) and its high-affinity receptor, tropomyosin receptor kinase B (TrkB) signaling plays a key role in the brain neurodevelopment. The exposure of pregnant mice to polyinosinic¿polycytidylic acid [poly(I:C)] causes cognitive deficits in adult offspring. Supplementation with a TrkB agonist, 7,8-dihydroxyflavone, in poly(I:C)-treated pregnant mice from pregnancy to weaning could prevent the onset of cognitive deficits and reduced BDNF¿TrkB signaling in the prefrontal cortex of their adult offspring. These findings suggest that supplementation with a TrkB agonist in pregnant women with an ultra-high risk of psychosis may reduce the development of psychosis in their offspring.

Authors


Publication Date


  • 2017

Citation


  • Han, M., Zhang, J., Huang, X. & Hashimoto, K. (2017). Intake of 7,8-dihydroxyflavone from pregnancy to weaning prevents cognitive deficits in adult offspring after maternal immune activation. European Archives of Psychiatry and Clinical Neuroscience: official organ of the German society for biological psychiatry, 267 (5), 479-483.

Scopus Eid


  • 2-s2.0-85017511452

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/1057

Has Global Citation Frequency


Number Of Pages


  • 4

Start Page


  • 479

End Page


  • 483

Volume


  • 267

Issue


  • 5

Place Of Publication


  • Germany