Skip to main content
placeholder image

Orbitofrontal and caudate volumes in cannabis users: a multi-site mega-analysis comparing dependent versus non-dependent users

Journal Article


Abstract


  • Rationale: Cannabis (CB) use and dependence are associated with regionally specific alterations to brain circuitry and substantial psychosocial impairment. Objectives: The objective of this study was to investigate the association between CB use and dependence, and the volumes of brain regions critically involved in goal-directed learning and behaviour┬┐the orbitofrontal cortex (OFC) and caudate. Methods: In the largest multi-site structural imaging study of CB users vs healthy controls (HC), 140 CB users and 121 HC were recruited from four research sites. Group differences in OFC and caudate volumes were investigated between HC and CB users and between 70 dependent (CB-dep) and 50 non-dependent (CB-nondep) users. The relationship between quantity of CB use and age of onset of use and caudate and OFC volumes was explored. Results: CB users (consisting of CB-dep and CB-nondep) did not significantly differ from HC in OFC or caudate volume. CB-dep compared to CB-nondep users exhibited significantly smaller volume in the medial and the lateral OFC. Lateral OFC volume was particularly smaller in CB-dep females, and reduced volume in the CB-dep group was associated with higher monthly cannabis dosage. Conclusions: Smaller medial OFC volume may be driven by CB dependence-related mechanisms, while smaller lateral OFC volume may be due to ongoing exposure to cannabinoid compounds. The results highlight a distinction between cannabis use and dependence and warrant examination of gender-specific effects in studies of CB dependence.

UOW Authors


  •   Chye, Yann (external author)
  •   Solowij, Nadia
  •   Suo, Chao (external author)
  •   Batalla, Albert (external author)
  •   Cousijn, Janna (external author)
  •   Goudriaan, Anna (external author)
  •   Martin-Santos, Rocio (external author)
  •   Whittle, Sarah (external author)
  •   Lorenzetti, Valentina (external author)
  •   Yucel, Murat (external author)

Publication Date


  • 2017

Citation


  • Chye, Y., Solowij, N., Suo, C., Batalla, A., Cousijn, J., Goudriaan, A., Martin-Santos, R., Whittle, S., Lorenzetti, V. & Yucel, M. (2017). Orbitofrontal and caudate volumes in cannabis users: a multi-site mega-analysis comparing dependent versus non-dependent users. Psychopharmacology, 234 (17), 1985-1995.

Scopus Eid


  • 2-s2.0-85016557926

Ro Metadata Url


  • http://ro.uow.edu.au/sspapers/2982

Has Global Citation Frequency


Number Of Pages


  • 10

Start Page


  • 1985

End Page


  • 1995

Volume


  • 234

Issue


  • 17

Place Of Publication


  • Germany

Abstract


  • Rationale: Cannabis (CB) use and dependence are associated with regionally specific alterations to brain circuitry and substantial psychosocial impairment. Objectives: The objective of this study was to investigate the association between CB use and dependence, and the volumes of brain regions critically involved in goal-directed learning and behaviour┬┐the orbitofrontal cortex (OFC) and caudate. Methods: In the largest multi-site structural imaging study of CB users vs healthy controls (HC), 140 CB users and 121 HC were recruited from four research sites. Group differences in OFC and caudate volumes were investigated between HC and CB users and between 70 dependent (CB-dep) and 50 non-dependent (CB-nondep) users. The relationship between quantity of CB use and age of onset of use and caudate and OFC volumes was explored. Results: CB users (consisting of CB-dep and CB-nondep) did not significantly differ from HC in OFC or caudate volume. CB-dep compared to CB-nondep users exhibited significantly smaller volume in the medial and the lateral OFC. Lateral OFC volume was particularly smaller in CB-dep females, and reduced volume in the CB-dep group was associated with higher monthly cannabis dosage. Conclusions: Smaller medial OFC volume may be driven by CB dependence-related mechanisms, while smaller lateral OFC volume may be due to ongoing exposure to cannabinoid compounds. The results highlight a distinction between cannabis use and dependence and warrant examination of gender-specific effects in studies of CB dependence.

UOW Authors


  •   Chye, Yann (external author)
  •   Solowij, Nadia
  •   Suo, Chao (external author)
  •   Batalla, Albert (external author)
  •   Cousijn, Janna (external author)
  •   Goudriaan, Anna (external author)
  •   Martin-Santos, Rocio (external author)
  •   Whittle, Sarah (external author)
  •   Lorenzetti, Valentina (external author)
  •   Yucel, Murat (external author)

Publication Date


  • 2017

Citation


  • Chye, Y., Solowij, N., Suo, C., Batalla, A., Cousijn, J., Goudriaan, A., Martin-Santos, R., Whittle, S., Lorenzetti, V. & Yucel, M. (2017). Orbitofrontal and caudate volumes in cannabis users: a multi-site mega-analysis comparing dependent versus non-dependent users. Psychopharmacology, 234 (17), 1985-1995.

Scopus Eid


  • 2-s2.0-85016557926

Ro Metadata Url


  • http://ro.uow.edu.au/sspapers/2982

Has Global Citation Frequency


Number Of Pages


  • 10

Start Page


  • 1985

End Page


  • 1995

Volume


  • 234

Issue


  • 17

Place Of Publication


  • Germany