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The central mechanism of risperidone-induced hyperprolactinemia

Journal Article


Abstract


  • Risperidone is known to increase prolactin secretion in treating mental illness patients. This side-effect is thought to be mediated via central signaling pathway. However, the exact pathway involved between risperidone and hyperprolactinemia are still unknown. Therefore, we have treated mice with risperidone and investigated the central mechanisms. The present study showed that in risperidone treated group, the level of the serum prolactin significantly increased, which was consistent with increased positive prolactin staining in pituitary gland. Elevated c-fos expression was observed in the arcuate hypothalamic nucleus (Arc) where we found 65% c-fos positive neurons co-localised with neuropeptide Y (NPY) in mice treated with risperidone. In addition, the results from in situ hybridization showed that the NPY mRNA in the Arc was significantly increased, whereas the tyrosine hydroxylase (TH) mRNA dramatically decreased compared with control group in the paraventricular hypothalamic nucleus (PVN). These findings revealed that risperidone may mediate the transcriptional regulation of Arc NPY and TH in the PVN. Furthermore, risperidone induced a decreased dopamine synthesis in the PVN and thus reduced the dopamine-induced inhibition of prolactin release, ultimately lead to hyperprolactinemia. Therefore, insights into these neuronal mechanisms open up potential new ways to treat schizophrenia patients in order to ameliorate hyperprolactinemia.

Authors


  •   Sun, Weiwei (external author)
  •   Li, Lin (external author)
  •   Huang, Xu-Feng
  •   Shi, Yan-Chuan (external author)
  •   Yang, He (external author)
  •   Song, Zhi-Yuan (external author)
  •   Lin, Shu

Publication Date


  • 2017

Citation


  • Sun, W., Li, L., Huang, X., Shi, Y., Yang, H., Song, Z. & Lin, S. (2017). The central mechanism of risperidone-induced hyperprolactinemia. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 76 134-139.

Scopus Eid


  • 2-s2.0-85016240894

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/4604

Has Global Citation Frequency


Number Of Pages


  • 5

Start Page


  • 134

End Page


  • 139

Volume


  • 76

Place Of Publication


  • United States

Abstract


  • Risperidone is known to increase prolactin secretion in treating mental illness patients. This side-effect is thought to be mediated via central signaling pathway. However, the exact pathway involved between risperidone and hyperprolactinemia are still unknown. Therefore, we have treated mice with risperidone and investigated the central mechanisms. The present study showed that in risperidone treated group, the level of the serum prolactin significantly increased, which was consistent with increased positive prolactin staining in pituitary gland. Elevated c-fos expression was observed in the arcuate hypothalamic nucleus (Arc) where we found 65% c-fos positive neurons co-localised with neuropeptide Y (NPY) in mice treated with risperidone. In addition, the results from in situ hybridization showed that the NPY mRNA in the Arc was significantly increased, whereas the tyrosine hydroxylase (TH) mRNA dramatically decreased compared with control group in the paraventricular hypothalamic nucleus (PVN). These findings revealed that risperidone may mediate the transcriptional regulation of Arc NPY and TH in the PVN. Furthermore, risperidone induced a decreased dopamine synthesis in the PVN and thus reduced the dopamine-induced inhibition of prolactin release, ultimately lead to hyperprolactinemia. Therefore, insights into these neuronal mechanisms open up potential new ways to treat schizophrenia patients in order to ameliorate hyperprolactinemia.

Authors


  •   Sun, Weiwei (external author)
  •   Li, Lin (external author)
  •   Huang, Xu-Feng
  •   Shi, Yan-Chuan (external author)
  •   Yang, He (external author)
  •   Song, Zhi-Yuan (external author)
  •   Lin, Shu

Publication Date


  • 2017

Citation


  • Sun, W., Li, L., Huang, X., Shi, Y., Yang, H., Song, Z. & Lin, S. (2017). The central mechanism of risperidone-induced hyperprolactinemia. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 76 134-139.

Scopus Eid


  • 2-s2.0-85016240894

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/4604

Has Global Citation Frequency


Number Of Pages


  • 5

Start Page


  • 134

End Page


  • 139

Volume


  • 76

Place Of Publication


  • United States