Abstract
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The rapid development of a variety of molecular contrast agents makes the multimodality bioimaging highly attractive
towards higher resolution, more sensitive, informative diagnosis. The key lies in the development of facile material
synthesis that allows the integration of multiple contrast agents, ideally in a way that each of the components should
be logically assembled to maximize their performances. Here, we report the one-pot programmable growth of
multifunctional heterogeneous nanocrystal with tunable size, shape, composition, and properties. We demonstrated a
facile one-pot hot-injection method to enable the highly selectively controlled growth of different sodium lanthanide
fluoride nanomaterials in either longitudinal or transversal directions with atomic scale precision. This technique
allows the upconversion luminescence signal, MRI signal and x-ray signal logically integrated and optimized within
one single versatile nanoplatform for multimode bioimaging. These findings suggest that the facile strategy developed
here have the promising to get the desired heterogeneous nanocrystals as an all-in-one contrast agent for integrated
and self-correlative multimodal bioimaging.