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Engineering skeletal muscle - from two to three dimensions

Journal Article


Abstract


  • Large skeletal muscle defects remain a challenge for pa-

    tients and surgeons alike. While small injuries resulting

    in tears and lacerations can be repaired by the body’s

    own regenerative mechanisms, loss of over 20% of muscle

    will lead to scarring, denervation and loss of function

    (Turner and Badylak, 2012). This can occur in cases of

    trauma, tumour, surgery and degenerative disease, which

    overwhelm the body’s repair mechanisms and result in

    changed anatomy and weakened muscle groups. Loss of

    limb is another consequence of these disease processes.

    Restoring mobility and independence is a major recon-

    structive challenge, for which tissue engineering may of-

    fer a solution.

Authors


  •   Ngan, Catherine (external author)
  •   Quigley, Anita F. (external author)
  •   Kapsa, Robert M. I.
  •   Choong, Peter (external author)

Publication Date


  • 2018

Citation


  • Ngan, C. G. Y., Quigley, A., Kapsa, R. M. I. & Choong, P. F. M. (2018). Engineering skeletal muscle - from two to three dimensions. Journal of Tissue Engineering and Regenerative Medicine, 12 (1), e1-e6.

Scopus Eid


  • 2-s2.0-85009231209

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/2493

Start Page


  • e1

End Page


  • e6

Volume


  • 12

Issue


  • 1

Place Of Publication


  • United States

Abstract


  • Large skeletal muscle defects remain a challenge for pa-

    tients and surgeons alike. While small injuries resulting

    in tears and lacerations can be repaired by the body’s

    own regenerative mechanisms, loss of over 20% of muscle

    will lead to scarring, denervation and loss of function

    (Turner and Badylak, 2012). This can occur in cases of

    trauma, tumour, surgery and degenerative disease, which

    overwhelm the body’s repair mechanisms and result in

    changed anatomy and weakened muscle groups. Loss of

    limb is another consequence of these disease processes.

    Restoring mobility and independence is a major recon-

    structive challenge, for which tissue engineering may of-

    fer a solution.

Authors


  •   Ngan, Catherine (external author)
  •   Quigley, Anita F. (external author)
  •   Kapsa, Robert M. I.
  •   Choong, Peter (external author)

Publication Date


  • 2018

Citation


  • Ngan, C. G. Y., Quigley, A., Kapsa, R. M. I. & Choong, P. F. M. (2018). Engineering skeletal muscle - from two to three dimensions. Journal of Tissue Engineering and Regenerative Medicine, 12 (1), e1-e6.

Scopus Eid


  • 2-s2.0-85009231209

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/2493

Start Page


  • e1

End Page


  • e6

Volume


  • 12

Issue


  • 1

Place Of Publication


  • United States