placeholder image

Evaluation of the Biocompatibility of Polypyrrole Implanted Subdurally in GAERS

Journal Article


Abstract


  • This blinded controlled prospective randomized study investigates the biocompatibility of polypyrrole (PPy) polymer that will be used for intracranial triggered release of anti-epileptic drugs (AEDs). Three by three millimeters PPy are implanted subdurally in six adult female genetic absence epilepsy rats from Strasbourg. Each rat has a polymer implanted on one side of the cortex and a sham craniotomy performed on the other side. After a period of seven weeks, rats are euthanized and parallel series of coronal sections are cut throughout the implant site. Four series of 15 sections are histological (hematoxylin and eosin) and immunohistochemically (neuron-specific nuclear protein, glial fibrillary acidic protein, and anti-CD68 antibody) stained and evaluated by three investigators. The results show that implanted PPy mats do not induce obvious inflammation, trauma, gliosis, and neuronal toxicity. Therefore the authors conclude the PPy used offer good histocompatibility with central nervous system cells and that PPy sheets can be used as intracranial, AED delivery implant.

Authors


  •   Bauquier, Sebastien (external author)
  •   McLean, Karen J. (external author)
  •   Jiang, Jonathan L. (external author)
  •   Boston, Ray (external author)
  •   Lai, Alan (external author)
  •   Yue, Zhilian
  •   Moulton, Simon E. (external author)
  •   Halliday, Amy J. (external author)
  •   Wallace, Gordon G.
  •   Cook, Mark J. (external author)

Publication Date


  • 2017

Citation


  • Bauquier, S. H., McLean, K. J., Jiang, J. L., Boston, R. C., Lai, A., Yue, Z., Moulton, S. E., Halliday, A. J., Wallace, G. & Cook, M. J. (2017). Evaluation of the Biocompatibility of Polypyrrole Implanted Subdurally in GAERS. Macromolecular Bioscience, 17 (5), 1600334-1-1600334-8.

Scopus Eid


  • 2-s2.0-85008256571

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/2460

Start Page


  • 1600334-1

End Page


  • 1600334-8

Volume


  • 17

Issue


  • 5

Place Of Publication


  • Germany

Abstract


  • This blinded controlled prospective randomized study investigates the biocompatibility of polypyrrole (PPy) polymer that will be used for intracranial triggered release of anti-epileptic drugs (AEDs). Three by three millimeters PPy are implanted subdurally in six adult female genetic absence epilepsy rats from Strasbourg. Each rat has a polymer implanted on one side of the cortex and a sham craniotomy performed on the other side. After a period of seven weeks, rats are euthanized and parallel series of coronal sections are cut throughout the implant site. Four series of 15 sections are histological (hematoxylin and eosin) and immunohistochemically (neuron-specific nuclear protein, glial fibrillary acidic protein, and anti-CD68 antibody) stained and evaluated by three investigators. The results show that implanted PPy mats do not induce obvious inflammation, trauma, gliosis, and neuronal toxicity. Therefore the authors conclude the PPy used offer good histocompatibility with central nervous system cells and that PPy sheets can be used as intracranial, AED delivery implant.

Authors


  •   Bauquier, Sebastien (external author)
  •   McLean, Karen J. (external author)
  •   Jiang, Jonathan L. (external author)
  •   Boston, Ray (external author)
  •   Lai, Alan (external author)
  •   Yue, Zhilian
  •   Moulton, Simon E. (external author)
  •   Halliday, Amy J. (external author)
  •   Wallace, Gordon G.
  •   Cook, Mark J. (external author)

Publication Date


  • 2017

Citation


  • Bauquier, S. H., McLean, K. J., Jiang, J. L., Boston, R. C., Lai, A., Yue, Z., Moulton, S. E., Halliday, A. J., Wallace, G. & Cook, M. J. (2017). Evaluation of the Biocompatibility of Polypyrrole Implanted Subdurally in GAERS. Macromolecular Bioscience, 17 (5), 1600334-1-1600334-8.

Scopus Eid


  • 2-s2.0-85008256571

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/2460

Start Page


  • 1600334-1

End Page


  • 1600334-8

Volume


  • 17

Issue


  • 5

Place Of Publication


  • Germany