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Reduced serum levels of oestradiol and brain derived neurotrophic factor in both diabetic women and HFD-feeding female mice

Journal Article


Abstract


  • The estrogen levels in the pre and post menstrual phases interact with brain-derived neurotrophic factor in a complex manner, which influences the overall state of the body. To study the role of oestradiol and brain-derived neurotrophic factor in modulating obesity related type 2 diabetes and the interactions between two factors, we enrolled 15 diabetic premenopausal women and 15 diabetic postmenopausal women respectively, the same number of healthy pre and postmenopausal women were recruited as two control groups. The fasting blood glucose, insulin, lipids, estrogen, and brain-derived neurotrophic factor levels were measured through clinical tests. Additionally, we set up obese female mouse model to mimic human trial stated above, to verify the relationship between estrogen and brain-derived neurotrophic factor. Our findings revealed that there is a moderately positive correlation between brain-derived neurotrophic factor and oestradiol in females, and decreased brain-derived neurotrophic factor may worsen impaired insulin function. The results further confirmed that high fat diet-fed mice which exhibited impaired glucose tolerance, showed lower levels of oestradiol and decreased expression of brain-derived neurotrophic factor mRNA in the ventromedial hypothalamus. The level of brain-derived neurotrophic factor reduced on condition that the level of oestradiol is sufficiently low, such as women in postmenopausal period, which aggravates diabetes through feeding-related pathways. Increasing the level of brain-derived neurotrophic factor may help to alleviate the progression of the disease in postmenopausal women with diabetes.

Authors


  •   Zhang, Yilian (external author)
  •   Zhang, Shan-Wen (external author)
  •   Khandekar, Neeta (external author)
  •   Tong, Shi-Fei (external author)
  •   Yang, He (external author)
  •   Wang, Wan-Ru (external author)
  •   Huang, Xu-Feng
  •   Song, Zhi-Yuan (external author)
  •   Lin, Shu

Publication Date


  • 2017

Citation


  • Zhang, Y., Zhang, S., Khandekar, N., Tong, S., Yang, H., Wang, W., Huang, X., Song, Z. & Lin, S. (2017). Reduced serum levels of oestradiol and brain derived neurotrophic factor in both diabetic women and HFD-feeding female mice. Endocrine, 56 (1), 65-72.

Scopus Eid


  • 2-s2.0-85006173447

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/4580

Number Of Pages


  • 7

Start Page


  • 65

End Page


  • 72

Volume


  • 56

Issue


  • 1

Place Of Publication


  • United States

Abstract


  • The estrogen levels in the pre and post menstrual phases interact with brain-derived neurotrophic factor in a complex manner, which influences the overall state of the body. To study the role of oestradiol and brain-derived neurotrophic factor in modulating obesity related type 2 diabetes and the interactions between two factors, we enrolled 15 diabetic premenopausal women and 15 diabetic postmenopausal women respectively, the same number of healthy pre and postmenopausal women were recruited as two control groups. The fasting blood glucose, insulin, lipids, estrogen, and brain-derived neurotrophic factor levels were measured through clinical tests. Additionally, we set up obese female mouse model to mimic human trial stated above, to verify the relationship between estrogen and brain-derived neurotrophic factor. Our findings revealed that there is a moderately positive correlation between brain-derived neurotrophic factor and oestradiol in females, and decreased brain-derived neurotrophic factor may worsen impaired insulin function. The results further confirmed that high fat diet-fed mice which exhibited impaired glucose tolerance, showed lower levels of oestradiol and decreased expression of brain-derived neurotrophic factor mRNA in the ventromedial hypothalamus. The level of brain-derived neurotrophic factor reduced on condition that the level of oestradiol is sufficiently low, such as women in postmenopausal period, which aggravates diabetes through feeding-related pathways. Increasing the level of brain-derived neurotrophic factor may help to alleviate the progression of the disease in postmenopausal women with diabetes.

Authors


  •   Zhang, Yilian (external author)
  •   Zhang, Shan-Wen (external author)
  •   Khandekar, Neeta (external author)
  •   Tong, Shi-Fei (external author)
  •   Yang, He (external author)
  •   Wang, Wan-Ru (external author)
  •   Huang, Xu-Feng
  •   Song, Zhi-Yuan (external author)
  •   Lin, Shu

Publication Date


  • 2017

Citation


  • Zhang, Y., Zhang, S., Khandekar, N., Tong, S., Yang, H., Wang, W., Huang, X., Song, Z. & Lin, S. (2017). Reduced serum levels of oestradiol and brain derived neurotrophic factor in both diabetic women and HFD-feeding female mice. Endocrine, 56 (1), 65-72.

Scopus Eid


  • 2-s2.0-85006173447

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/4580

Number Of Pages


  • 7

Start Page


  • 65

End Page


  • 72

Volume


  • 56

Issue


  • 1

Place Of Publication


  • United States