Skip to main content
placeholder image

A 6-month randomised controlled trial investigating effects of Mediterranean-style diet and fish oil supplementation on dietary behaviour change, mental and cardiometabolic health and health-related quality of life in adults with depression (HELFIMED): study protocol

Journal Article


Abstract


  • Background: Modern diets, characterised by excess consumption of processed foods, are accompanied by an

    epidemic of chronic diseases. Cardiovascular disease and depression carry a large burden of disease and often occur

    together. Poor dietary patterns have been identified as an independent risk factor for depression while healthy diets

    with minimally processed food are protective. Traditional Mediterranean diets have been shown to reduce risk of

    cardiovascular disease; however there is a need for clinical trials in people with depression. This paper reports the study

    protocol of a Mediterranean-style diet intervention conducted in adults with self-reported depression.

    Methods/design: HELFIMED is a parallel 6-month randomised controlled trial investigating whether dietary patterns

    can be improved in people with depressive symptoms and whether healthier diet combined with fish oil

    supplementation can improve mental and cardiometabolic health and quality of life. Adults aged 18–65 years with selfreported

    depressive symptoms over the previous two months (N = 163) were block-randomised on age and gender

    between May 2014 and June 2015 to receive nutrition education, food hampers, fortnightly cooking workshops based

    on Mediterranean-style dietary principles for 3 months and fish oil supplementation for 6 months, or to attend

    fortnightly social groups (control group) for 3 months. All participants completed mental health (DASS and PANAS),

    quality of life, dietary and shopping and budgeting questionnaires and provided anthropometric measurements, blood

    and urine samples at baseline, 3 and 6 months. Additionally the treatment group attended focus groups at 3 and

    6 months. Primary and secondary outcomes will be analysed using linear mixed modelling and correlations will

    investigate associations between improved health outcomes and subjective/objective measures of improved diet/

    nutritional status.Discussion: This study will contribute causal evidence to prior observational and longitudinal studies that have shown

    associations between Mediterranean diet and mental health. The results will inform public health and clinical strategies

    for treatment of depression and comorbid cardiometabolic risk factors.

Authors


  •   Zarnowiecki, Dorota M. (external author)
  •   Cho, Jihyun (external author)
  •   Wilson, Amy (external author)
  •   Bogomolova, Svetlana (external author)
  •   Villani, Anthony (external author)
  •   Itsiopoulos, Catherine (external author)
  •   Niyonsenga, Theo (external author)
  •   O'Dea, Kerin (external author)
  •   Blunden, Sarah (external author)
  •   Meyer, Barbara J.
  •   Segal, Leonie (external author)
  •   Parletta, Natalie (external author)

Publication Date


  • 2016

Citation


  • Zarnowiecki, D., Cho, J., Wilson, A., Bogomolova, S., Villani, A., Itsiopoulos, C., Niyonsenga, T., O'Dea, K., Blunden, S., Meyer, B., Segal, L. & Parletta, N. (2016). A 6-month randomised controlled trial investigating effects of Mediterranean-style diet and fish oil supplementation on dietary behaviour change, mental and cardiometabolic health and health-related quality of life in adults with depression (HELFIMED): study protocol. BMC Nutrition, 52 (2), 1-10.

Number Of Pages


  • 9

Start Page


  • 1

End Page


  • 10

Volume


  • 52

Issue


  • 2

Abstract


  • Background: Modern diets, characterised by excess consumption of processed foods, are accompanied by an

    epidemic of chronic diseases. Cardiovascular disease and depression carry a large burden of disease and often occur

    together. Poor dietary patterns have been identified as an independent risk factor for depression while healthy diets

    with minimally processed food are protective. Traditional Mediterranean diets have been shown to reduce risk of

    cardiovascular disease; however there is a need for clinical trials in people with depression. This paper reports the study

    protocol of a Mediterranean-style diet intervention conducted in adults with self-reported depression.

    Methods/design: HELFIMED is a parallel 6-month randomised controlled trial investigating whether dietary patterns

    can be improved in people with depressive symptoms and whether healthier diet combined with fish oil

    supplementation can improve mental and cardiometabolic health and quality of life. Adults aged 18–65 years with selfreported

    depressive symptoms over the previous two months (N = 163) were block-randomised on age and gender

    between May 2014 and June 2015 to receive nutrition education, food hampers, fortnightly cooking workshops based

    on Mediterranean-style dietary principles for 3 months and fish oil supplementation for 6 months, or to attend

    fortnightly social groups (control group) for 3 months. All participants completed mental health (DASS and PANAS),

    quality of life, dietary and shopping and budgeting questionnaires and provided anthropometric measurements, blood

    and urine samples at baseline, 3 and 6 months. Additionally the treatment group attended focus groups at 3 and

    6 months. Primary and secondary outcomes will be analysed using linear mixed modelling and correlations will

    investigate associations between improved health outcomes and subjective/objective measures of improved diet/

    nutritional status.Discussion: This study will contribute causal evidence to prior observational and longitudinal studies that have shown

    associations between Mediterranean diet and mental health. The results will inform public health and clinical strategies

    for treatment of depression and comorbid cardiometabolic risk factors.

Authors


  •   Zarnowiecki, Dorota M. (external author)
  •   Cho, Jihyun (external author)
  •   Wilson, Amy (external author)
  •   Bogomolova, Svetlana (external author)
  •   Villani, Anthony (external author)
  •   Itsiopoulos, Catherine (external author)
  •   Niyonsenga, Theo (external author)
  •   O'Dea, Kerin (external author)
  •   Blunden, Sarah (external author)
  •   Meyer, Barbara J.
  •   Segal, Leonie (external author)
  •   Parletta, Natalie (external author)

Publication Date


  • 2016

Citation


  • Zarnowiecki, D., Cho, J., Wilson, A., Bogomolova, S., Villani, A., Itsiopoulos, C., Niyonsenga, T., O'Dea, K., Blunden, S., Meyer, B., Segal, L. & Parletta, N. (2016). A 6-month randomised controlled trial investigating effects of Mediterranean-style diet and fish oil supplementation on dietary behaviour change, mental and cardiometabolic health and health-related quality of life in adults with depression (HELFIMED): study protocol. BMC Nutrition, 52 (2), 1-10.

Number Of Pages


  • 9

Start Page


  • 1

End Page


  • 10

Volume


  • 52

Issue


  • 2