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X-Tream quality assurance in synchrotron X-ray microbeam radiation therapy

Journal Article


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Abstract


  • Microbeam radiation therapy (MRT) is a novel irradiation technique for brain

    tumours treatment currently under development at the European Synchrotron

    Radiation Facility in Grenoble, France. The technique is based on the spatial

    fractionation of a highly brilliant synchrotron X-ray beam into an array of

    microbeams using a multi-slit collimator (MSC). After promising pre-clinical

    results, veterinary trials have recently commenced requiring the need for

    dedicated quality assurance (QA) procedures. The quality of MRT treatment

    demands reproducible and precise spatial fractionation of the incoming

    synchrotron beam. The intensity profile of the microbeams must also be quickly

    and quantitatively characterized prior to each treatment for comparison with

    that used for input to the dose-planning calculations. The Centre for Medical

    Radiation Physics (University of Wollongong, Australia) has developed an

    X-ray treatment monitoring system (X-Tream) which incorporates a highspatial-

    resolution silicon strip detector (SSD) specifically designed for MRT. Inair

    measurements of the horizontal profile of the intrinsic microbeam X-ray field

    in order to determine the relative intensity of each microbeam are presented,

    and the alignment of the MSC is also assessed. The results show that the SSD is

    able to resolve individual microbeams which therefore provides invaluable QA

    of the horizontal field size and microbeam number and shape. They also

    demonstrate that the SSD used in the X-Tream system is very sensitive to any

    small misalignment of the MSC. In order to allow as rapid QA as possible, a fast

    alignment procedure of the SSD based on X-ray imaging with a low-intensity

    low-energy beam has been developed and is presented in this publication.

UOW Authors


  •   Fournier, Pauline (external author)
  •   Cornelius, Iwan (external author)
  •   Donzelli, Mattia (external author)
  •   Requardt, Herwig (external author)
  •   Nemoz, Christian (external author)
  •   Petasecca, Marco
  •   Brauer-Krisch, Elke (external author)
  •   Rosenfeld, Anatoly B.
  •   Lerch, Michael

Publication Date


  • 2016

Citation


  • Fournier, P., Cornelius, I., Donzelli, M., Requardt, H., Nemoz, C., Petasecca, M., Brauer-Krisch, E., Rosenfeld, A. & Lerch, M. (2016). X-Tream quality assurance in synchrotron X-ray microbeam radiation therapy. Journal of Synchrotron Radiation, 23 (5), 1180-1190.

Scopus Eid


  • 2-s2.0-84984904247

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=7153&context=eispapers

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/6123

Number Of Pages


  • 10

Start Page


  • 1180

End Page


  • 1190

Volume


  • 23

Issue


  • 5

Abstract


  • Microbeam radiation therapy (MRT) is a novel irradiation technique for brain

    tumours treatment currently under development at the European Synchrotron

    Radiation Facility in Grenoble, France. The technique is based on the spatial

    fractionation of a highly brilliant synchrotron X-ray beam into an array of

    microbeams using a multi-slit collimator (MSC). After promising pre-clinical

    results, veterinary trials have recently commenced requiring the need for

    dedicated quality assurance (QA) procedures. The quality of MRT treatment

    demands reproducible and precise spatial fractionation of the incoming

    synchrotron beam. The intensity profile of the microbeams must also be quickly

    and quantitatively characterized prior to each treatment for comparison with

    that used for input to the dose-planning calculations. The Centre for Medical

    Radiation Physics (University of Wollongong, Australia) has developed an

    X-ray treatment monitoring system (X-Tream) which incorporates a highspatial-

    resolution silicon strip detector (SSD) specifically designed for MRT. Inair

    measurements of the horizontal profile of the intrinsic microbeam X-ray field

    in order to determine the relative intensity of each microbeam are presented,

    and the alignment of the MSC is also assessed. The results show that the SSD is

    able to resolve individual microbeams which therefore provides invaluable QA

    of the horizontal field size and microbeam number and shape. They also

    demonstrate that the SSD used in the X-Tream system is very sensitive to any

    small misalignment of the MSC. In order to allow as rapid QA as possible, a fast

    alignment procedure of the SSD based on X-ray imaging with a low-intensity

    low-energy beam has been developed and is presented in this publication.

UOW Authors


  •   Fournier, Pauline (external author)
  •   Cornelius, Iwan (external author)
  •   Donzelli, Mattia (external author)
  •   Requardt, Herwig (external author)
  •   Nemoz, Christian (external author)
  •   Petasecca, Marco
  •   Brauer-Krisch, Elke (external author)
  •   Rosenfeld, Anatoly B.
  •   Lerch, Michael

Publication Date


  • 2016

Citation


  • Fournier, P., Cornelius, I., Donzelli, M., Requardt, H., Nemoz, C., Petasecca, M., Brauer-Krisch, E., Rosenfeld, A. & Lerch, M. (2016). X-Tream quality assurance in synchrotron X-ray microbeam radiation therapy. Journal of Synchrotron Radiation, 23 (5), 1180-1190.

Scopus Eid


  • 2-s2.0-84984904247

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=7153&context=eispapers

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/6123

Number Of Pages


  • 10

Start Page


  • 1180

End Page


  • 1190

Volume


  • 23

Issue


  • 5