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PZP and PAI-2: structurally-diverse, functionally similar pregnancy proteins?

Journal Article


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Abstract


  • Pregnancy zone protein (PZP) and plasminogen activator inhibitor type 2 (PAI-2) are two multifunctional proteins that are elevated in normal pregnancy and numerous other inflammatory states. Both proteins were originally identified as protease inhibitors, but current evidence supports the notion that they may also function as modulators of T-helper cells and/or extracellular chaperones. Exacerbated inflammation, fibrinolytic disturbances and misfolded proteins are all implicated in the pathology of preeclampsia, a leading cause of maternal and foetal mortality and morbidity. Notably, reduced levels of PZP or PAI-2 are associated with preeclampsia and clarification of their diverse functions in normal pregnancy could provide much needed insight regarding the pathogenesis of this disorder. Given that inflammation and protein misfolding underlie the pathology of a very large number of disorders, the contributions of PZP and PAI-2 to extracellular proteostasis and immunoregulation could be broad-reaching.

Publication Date


  • 2016

Citation


  • Wyatt, A. R., Cater, J. H. & Ranson, M. (2016). PZP and PAI-2: structurally-diverse, functionally similar pregnancy proteins?. The International Journal of Biochemistry and Cell Biology, 79 113-117.

Scopus Eid


  • 2-s2.0-84983249711

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=5075&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/4051

Number Of Pages


  • 4

Start Page


  • 113

End Page


  • 117

Volume


  • 79

Abstract


  • Pregnancy zone protein (PZP) and plasminogen activator inhibitor type 2 (PAI-2) are two multifunctional proteins that are elevated in normal pregnancy and numerous other inflammatory states. Both proteins were originally identified as protease inhibitors, but current evidence supports the notion that they may also function as modulators of T-helper cells and/or extracellular chaperones. Exacerbated inflammation, fibrinolytic disturbances and misfolded proteins are all implicated in the pathology of preeclampsia, a leading cause of maternal and foetal mortality and morbidity. Notably, reduced levels of PZP or PAI-2 are associated with preeclampsia and clarification of their diverse functions in normal pregnancy could provide much needed insight regarding the pathogenesis of this disorder. Given that inflammation and protein misfolding underlie the pathology of a very large number of disorders, the contributions of PZP and PAI-2 to extracellular proteostasis and immunoregulation could be broad-reaching.

Publication Date


  • 2016

Citation


  • Wyatt, A. R., Cater, J. H. & Ranson, M. (2016). PZP and PAI-2: structurally-diverse, functionally similar pregnancy proteins?. The International Journal of Biochemistry and Cell Biology, 79 113-117.

Scopus Eid


  • 2-s2.0-84983249711

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=5075&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/4051

Number Of Pages


  • 4

Start Page


  • 113

End Page


  • 117

Volume


  • 79