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An MRI study of white matter tract integrity in regular cannabis users: effects of cannabis use and age

Journal Article


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Abstract


  • Rationale

    Conflicting evidence exists on the effects of cannabis use on brain white matter integrity. The extant literature has exclusively focused on younger cannabis users, with no studies sampling older cannabis users.

    Objectives

    We recruited a sample with a broad age range to examine the integrity of major white matter tracts in association with cannabis use parameters and neurodevelopmental stage.

    Methods

    Regular cannabis users (n = 56) and non-users (n = 20) with a mean age of 32 (range 18–55 years) underwent structural and diffusion MRI scans. White matter was examined using voxel-based statistics and via probabilistic tract reconstruction. The integrity of tracts was assessed using average fractional anisotropy, axial diffusivity and radial diffusivity. Diffusion measures were compared between users and non-users and as group-by-age interactions. Correlations between diffusion measures and age of onset, duration, frequency and dose of current cannabis use were examined.

    Results

    Cannabis users overall had lower fractional anisotropy than healthy non-users in the forceps minor tract only (p = .015, partial eta = 0.07), with no voxel-wise differences observed. Younger users showed predominantly reduced axial diffusivity, whereas older users had higher radial diffusivity in widespread tracts. Higher axial diffusivity was associated with duration of cannabis use in the cingulum angular bundle (beta = 5.00 × 10−5, p = .003). Isolated higher AD in older cannabis users was also observed.

    Conclusions

    The findings suggest that exogenous cannabinoids alter normal brain maturation, with differing effects at various neurodevelopmental stages of life. These age-related differences are posited to account for the disparate results described in the literature.

UOW Authors


  •   Jakabek, David D. (external author)
  •   Yucel, Murat (external author)
  •   Lorenzetti, Valentina (external author)
  •   Solowij, Nadia

Publication Date


  • 2016

Citation


  • Jakabek, D., Yücel, M., Lorenzetti, V. & Solowij, N. (2016). An MRI study of white matter tract integrity in regular cannabis users: effects of cannabis use and age. Psychopharmacology, 233 (19), 3627-3637.

Scopus Eid


  • 2-s2.0-84981164752

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1928&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/904

Has Global Citation Frequency


Number Of Pages


  • 10

Start Page


  • 3627

End Page


  • 3637

Volume


  • 233

Issue


  • 19

Place Of Publication


  • Germany

Abstract


  • Rationale

    Conflicting evidence exists on the effects of cannabis use on brain white matter integrity. The extant literature has exclusively focused on younger cannabis users, with no studies sampling older cannabis users.

    Objectives

    We recruited a sample with a broad age range to examine the integrity of major white matter tracts in association with cannabis use parameters and neurodevelopmental stage.

    Methods

    Regular cannabis users (n = 56) and non-users (n = 20) with a mean age of 32 (range 18–55 years) underwent structural and diffusion MRI scans. White matter was examined using voxel-based statistics and via probabilistic tract reconstruction. The integrity of tracts was assessed using average fractional anisotropy, axial diffusivity and radial diffusivity. Diffusion measures were compared between users and non-users and as group-by-age interactions. Correlations between diffusion measures and age of onset, duration, frequency and dose of current cannabis use were examined.

    Results

    Cannabis users overall had lower fractional anisotropy than healthy non-users in the forceps minor tract only (p = .015, partial eta = 0.07), with no voxel-wise differences observed. Younger users showed predominantly reduced axial diffusivity, whereas older users had higher radial diffusivity in widespread tracts. Higher axial diffusivity was associated with duration of cannabis use in the cingulum angular bundle (beta = 5.00 × 10−5, p = .003). Isolated higher AD in older cannabis users was also observed.

    Conclusions

    The findings suggest that exogenous cannabinoids alter normal brain maturation, with differing effects at various neurodevelopmental stages of life. These age-related differences are posited to account for the disparate results described in the literature.

UOW Authors


  •   Jakabek, David D. (external author)
  •   Yucel, Murat (external author)
  •   Lorenzetti, Valentina (external author)
  •   Solowij, Nadia

Publication Date


  • 2016

Citation


  • Jakabek, D., Yücel, M., Lorenzetti, V. & Solowij, N. (2016). An MRI study of white matter tract integrity in regular cannabis users: effects of cannabis use and age. Psychopharmacology, 233 (19), 3627-3637.

Scopus Eid


  • 2-s2.0-84981164752

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1928&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/904

Has Global Citation Frequency


Number Of Pages


  • 10

Start Page


  • 3627

End Page


  • 3637

Volume


  • 233

Issue


  • 19

Place Of Publication


  • Germany