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Two new bioactive iridoids from Rothmannia wittii

Journal Article


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Abstract


  • The first reported study of the isolation and identification of compounds from the bark and fruit of Rothmannia wittii yielded two new iridoids, 6β-hydroxy-10-O-acetylgenipin (1) and 10-O-acetylmacrophyllide (2) together with six known iridoids; 6β-hydroxygenipin (3), genipin (4), garjasmine (5), cerbinal (6), and mixture of β-gardiol (7) and α-gardiol (8); benzoic acid (9); vanillic acid (10); and stigmasterol (11). Their structures were elucidated by spectroscopic methods. Iridoid 1 showed antimycobacterial activity against Mycobacterium tuberculosis with a MIC value of 12.50 μg/mL. Iridoid 2 showed cytotoxicity against the NCI-H187 cancer cell line with an IC50 value of 6.82 μg/mL. In addition, 2 and 5 exhibited weak cytotoxic activity against KB and MCF-7 cell lines, while 4 was active against the NCI-H187 cancer cell line.

UOW Authors


  •   Chaipukdee, Nattapong (external author)
  •   Kanokmedhakul, Kwanjai (external author)
  •   Kanokmedhakul, Somdej (external author)
  •   Lekphrom, Ratsami (external author)
  •   Pyne, Stephen

Publication Date


  • 2016

Citation


  • Chaipukdee, N., Kanokmedhakul, K., Kanokmedhakul, S., Lekphrom, R. & Pyne, S. G. (2016). Two new bioactive iridoids from Rothmannia wittii. Fitoterapia, 113 97-101.

Scopus Eid


  • 2-s2.0-84978636436

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=5035&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/4011

Has Global Citation Frequency


Number Of Pages


  • 4

Start Page


  • 97

End Page


  • 101

Volume


  • 113

Place Of Publication


  • Netherlands

Abstract


  • The first reported study of the isolation and identification of compounds from the bark and fruit of Rothmannia wittii yielded two new iridoids, 6β-hydroxy-10-O-acetylgenipin (1) and 10-O-acetylmacrophyllide (2) together with six known iridoids; 6β-hydroxygenipin (3), genipin (4), garjasmine (5), cerbinal (6), and mixture of β-gardiol (7) and α-gardiol (8); benzoic acid (9); vanillic acid (10); and stigmasterol (11). Their structures were elucidated by spectroscopic methods. Iridoid 1 showed antimycobacterial activity against Mycobacterium tuberculosis with a MIC value of 12.50 μg/mL. Iridoid 2 showed cytotoxicity against the NCI-H187 cancer cell line with an IC50 value of 6.82 μg/mL. In addition, 2 and 5 exhibited weak cytotoxic activity against KB and MCF-7 cell lines, while 4 was active against the NCI-H187 cancer cell line.

UOW Authors


  •   Chaipukdee, Nattapong (external author)
  •   Kanokmedhakul, Kwanjai (external author)
  •   Kanokmedhakul, Somdej (external author)
  •   Lekphrom, Ratsami (external author)
  •   Pyne, Stephen

Publication Date


  • 2016

Citation


  • Chaipukdee, N., Kanokmedhakul, K., Kanokmedhakul, S., Lekphrom, R. & Pyne, S. G. (2016). Two new bioactive iridoids from Rothmannia wittii. Fitoterapia, 113 97-101.

Scopus Eid


  • 2-s2.0-84978636436

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=5035&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/4011

Has Global Citation Frequency


Number Of Pages


  • 4

Start Page


  • 97

End Page


  • 101

Volume


  • 113

Place Of Publication


  • Netherlands